RNF34 Protein (AA 1-373) (His tag)

Produktnummer ABIN5853359

Produktdetails

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-373

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses RNF34 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSMRKAGAT SMWASCCGLL NEVMGTGAVR GQQSAFAGAT GPFRFTPNPE FSTYPPAATE GPNIVCKACG LSFSVFRKKH VCCDCKKDFC SVCSVLQENL RRCSTCHLLQ ETAFQRPQLM RLKVKDLRQY LILRNIPIDT CREKEDLVDL VLCHHGLGSE DDMDTSSLNS SRSQTSSFFT RSFFSNYTAP SATMSSFQGE LMDGDQTSRS GVPAQVQSEI TSANTEDDDD DDDEDDDDEE ENAEDRNPGL SKERVRASLS DLSSLDDVEG MSVRQLKEIL ARNFVNYSGC CEKWELVEKV NRLYKENEEN QKSYGERLQL QDEEDDSLCR ICMDAVIDCV LLECGHMVTC TKCGKRMSEC PICRQYVVRA VHVFKS

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. 20  mM Tris-HCl buffer (  pH 8.0) containing 10 % glycerol 0.1M NaCl, 1  mM DTT

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Andere Bezeichnung: RNF34 (RNF34 Produkte)

Synonyme: CARP-1 Protein, CARP1 Protein, RFI Protein, RIF Protein, RIFF Protein, hRFI Protein, rnf34 Protein, AW061037 Protein, AW536122 Protein, BC004042 Protein, C88279 Protein, Momo Protein, fi35g06 Protein, wu:fi35g06 Protein, zgc:114043 Protein, zgc:171755 Protein, ring finger protein 34 Protein, E3 ubiquitin-protein ligase RNF34 Protein, ring finger protein 34a Protein, ring finger protein 34b Protein, Residual feed intake Protein, RNF34 Protein, rnf34 Protein, Rnf34 Protein, rnf34a Protein, rnf34b Protein, RFI Protein

Hintergrund: RNF34contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. Recombinant human RNF34 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molekulargewicht: 44.2 kDa(396aa) confirmed by MALDI-TOF

NCBI Accession: NP_919247

UniProt: Q969K3