GNB3 Protein (AA 1-340) (His tag)

Produktnummer ABIN5853311

Produktdetails

Target: GNB3 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 3 (GNB3))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-340

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses GNB3 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSMGEMEQL RQEAEQLKKQ IADARKACAD VTLAELVSGL EVVGRVQMRT RRTLRGHLAK IYAMHWATDS KLLVSASQDG KLIVWDSYTT NKVHAIPLRS SWVMTCAYAP SGNFVACGGL DNMCSIYNLK SREGNVKVSR ELSAHTGYLS CCRFLDDNNI VTSSGDTTCA LWDIETGQQK TVFVGHTGDC MSLAVSPDFN LFISGACDAS AKLWDVREGT CRQTFTGHES DINAICFFPN GEAICTGSDD ASCRLFDLRA DQELICFSHE SIICGITSVA FSLSGRLLFA GYDDFNCNVW DSMKSERVGI LSGHDNRVSC LGVTADGMAV ATGSWDSFLK IWN

Reinheit: > 80 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Denatured

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Liquid. 20  mM Tris-HCl buffer (  pH 8.0) containing 10 % glycerol 0.4M urea

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: GNB3 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 3 (GNB3))

Andere Bezeichnung: GNB3 (GNB3 Produkte)

Synonyme: Gnb-3 Protein, MGC68913 Protein, MGC130764 Protein, gnb3 Protein, zgc:73058 Protein, zgc:77780 Protein, wu:fk54b04 Protein, gnb3l Protein, zgc:92641 Protein, G protein subunit beta 3 Protein, guanine nucleotide binding protein (G protein), beta 3 Protein, guanine nucleotide binding protein (G protein), beta polypeptide 3 S homeolog Protein, guanine nucleotide binding protein (G protein), beta polypeptide 3b Protein, guanine nucleotide binding protein (G protein), beta polypeptide 3a Protein, GNB3 Protein, Gnb3 Protein, gnb3.S Protein, gnb3b Protein, gnb3a Protein

Hintergrund: GNB3 is important regulator of alpha subunit, as well as of certain signal transduction receptor and effector. A single-nucleotide polymorphism (C825T) in this protein is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described. Recombinant human GNB3 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molekulargewicht: 39.6 kDa(363aa)

NCBI Accession: NP_002066

UniProt: P16520

Pathways: Peptide Hormone Metabolism, Myometrial Relaxation and Contraction