2PP2A Protein, I2PP2A Protein, IGAAD Protein, IPP2A2 Protein, PHAPII Protein, TAF-I Protein, TAF-IBETA Protein, 2610030F17Rik Protein, 5730420M11Rik Protein, AA407739 Protein, I-2PP2A Protein, StF-IT-1 Protein, 2pp2a Protein, i2pp2a Protein, igaad Protein, ipp2a2 Protein, phapii Protein, set Protein, set-a Protein, set-b Protein, taf-ibeta Protein, wu:fb30g11 Protein, wu:fd16c08 Protein, SET nuclear proto-oncogene Protein, SET nuclear oncogene Protein, SET translocation Protein, SET nuclear proto-oncogene L homeolog Protein, SET nuclear proto-oncogene b Protein, SET Protein, Set Protein, LOC403555 Protein, set.L Protein, setb Protein
Hintergrund
SET inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. Recombinant human SET protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Molekulargewicht
35.9 kDa (313aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)