FHIT Protein (AA 2-147) (His tag)

Produktnummer ABIN5712778

Produktdetails

Target: FHIT (Fragile Histidine Triad (FHIT))

Protein-Typ: Recombinant

Proteineigenschaft: AA 2-147

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses FHIT Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: SFRFGQHLIK PSVVFLKTEL SFALVNRKPV VPGHVLVCPL RPVERFHDLR PDEVADLFQT TQRVGTVVEK HFHGTSLTFS MQDGPEAGQT VKHVHVHVLP RKAGDFHRND SIYEELQKHD KEDFPASWRS EEEMAAEAAA LRVYFQ

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: FHIT (Fragile Histidine Triad (FHIT))

Andere Bezeichnung: FHIT (FHIT Produkte)

Synonyme: AP3Aase Protein, FRA3B Protein, FHIT Protein, zgc:73176 Protein, AW045638 Protein, Fra14A2 Protein, LOC100223655 Protein, fragile histidine triad Protein, fragile histidine triad gene Protein, fragile histidine triad protein Protein, fragile histidine triad L homeolog Protein, FHIT Protein, Fhit Protein, fhit Protein, PY07476 Protein, fhit.L Protein

Hintergrund: Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extrely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor

Molekulargewicht: 20.8 kDa

UniProt: P49789