MCAM Protein (AA 50-646, partial) (His tag)

Produktnummer ABIN5712730

Produktdetails

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Protein-Typ: Recombinant

Proteineigenschaft: partial, AA 50-646

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses MCAM Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: LSQSQGNLSH VDWFSVHKEK RTLIFRVRQG QGQSEPGEYE QRLSLQDRGA TLALTQVTPQ DERIFLCQGK RPRSQEYRIQ LRVYKAPEEP NIQVNPLGIP VNSKEPEEVA TCVGRNGYPI PQVIWYKNGR PLKEEKNRVH IQSSQTVESS GLYTLQSILK AQLVKEDKDA QFYCELNYRL PSGNHMKESR EVTVPVFYPT EKVWLEVEPV GMLKEGDRVE IRCLADGNPP PHFSISKQNP STREAEEETT NDNGVLVLEP ARKEHSGRYE CQGLDLDTMI SLLSEPQELL VNYVSDVRVS PAAPERQEGS SLTLTCEAES SQDLEFQWLR EETGQVLERG PVLQLHDLKR EAGGGYRCVA SVPSIPGLNR TQLVNVAIFG PPWMAFKERK VWVKENMVLN LSCEASGHPR PTISWNVNGT ASEQDQDPQR VLSTLNVLVT PELLETGVEC TASNDLGKNT SILFLELVNL TTLTPDSNTT TGLSTSTASP HTRANSTSTE RKLPEPESRG VVIVAVIVCI LVLAVLGAVL YFLYKKGKLP CRRSGKQEIT LPPSRKSELV VEVKSDKLPE EMGLLQGSSG DKRAPGDQGE KYIDLRH

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: MCAM (Melanoma Cell Adhesion Molecule (MCAM))

Andere Bezeichnung: MUC18 (MCAM Produkte)

Synonyme: CD146 Protein, MUC18 Protein, Muc18 Protein, 1-gicerin Protein, AV025631 Protein, CD149 Protein, s-endo Protein, s-gicerin Protein, cd146 Protein, gicerin Protein, id:ibd3512 Protein, mcam Protein, MCAM Protein, melanoma cell adhesion molecule Protein, melanoma cell adhesion molecule b Protein, MCAM Protein, Mcam Protein, mcamb Protein

Hintergrund: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elents of the vascular syst, thereby enhancing hatogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during bryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Molekulargewicht: 70.7 kDa

UniProt: P43121