DYNLL1 Protein (AA 1-89, full length) (GST tag)

Produktnummer ABIN5712129

Produktdetails

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Protein-Typ: Recombinant

Proteineigenschaft: full length, AA 1-89

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses DYNLL1 Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: DYNLL1 (Dynein, Light Chain, LC8-Type 1 (DYNLL1))

Andere Bezeichnung: DYL1 (DYNLL1 Produkte)

Synonyme: DLC1 Protein, DLC8 Protein, DNCL1 Protein, DNCLC1 Protein, LC8 Protein, LC8a Protein, PIN Protein, hdlc1 Protein, dynll2 Protein, wu:fd56c09 Protein, zgc:73406 Protein, Dlc8 Protein, Dnclc1 Protein, Pin Protein, 8kDLC Protein, lc8 Protein, dlc1 Protein, dlc8 Protein, lc8a Protein, dncl1 Protein, dnclc1 Protein, dynll1a Protein, MGC68763 Protein, CDLC2 Protein, dynll1 Protein, dynll1b Protein, pin Protein, MGC89636 Protein, dynein light chain LC8-type 1 Protein, dynein, light chain, LC8-type 1 Protein, dynein light chain LC8-type 1 S homeolog Protein, dynein light chain LC8-type 1 L homeolog Protein, Dynein light chain 1, cytoplasmic Protein, DYNLL1 Protein, dynll1 Protein, Dynll1 Protein, dynll1.S Protein, dynll1.L Protein, dlc-1 Protein

Hintergrund: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Molekulargewicht: 37.8 kDa

UniProt: P63167

Pathways: M Phase, Tube Formation, Positive Regulation of Endopeptidase Activity