NEIL1 Protein (AA 2-390) (His-SUMO Tag)
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- Target Alle NEIL1 Proteine anzeigen
- NEIL1 (Endonuclease VIII-Like 1 (NEIL1))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 2-390
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses NEIL1 Protein ist gelabelt mit His-SUMO Tag.
- Applikation
- SDS-PAGE (SDS)
- Sequenz
- PEGPELHLAS QFVNEACRAL VFGGCVEKSS VSRNPEVPFE SSAYRISASA RGKELRLILS PLPGAQPQQE PLALVFRFGM SGSFQLVPRE ELPRHAHLRF YTAPPGPRLA LCFVDIRRFG RWDLGGKWQP GRGPCVLQEY QQFRENVLRN LADKAFDRPI CEALLDQRFF NGIGNYLRAE ILYRLKIPPF EKARSVLEAL QQHRPSPELT LSQKIRTKLQ NPDLLELCHS VPKEVVQLGG RGYGSESGEE DFAAFRAWLR CYGMPGMSSL QDRHGRTIWF QGDPGPLAPK GRKSRKKKSK ATQLSPEDRV EDALPPSKAP SRTRRAKRDL PKRTATQRPE GTSLQQDPEA PTVPKKGRRK GRQAASGHCR PRKVKADIPS LEPEGTSAS
- Aufreinigung
- SDS-PAGE
- Reinheit
- > 90 %
- Top Product
- Discover our top product NEIL1 Protein
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Endonuclease VIII-Like 1 (NEIL1) (AA 302-390) protein (GST tag)
NEIL1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Endonuclease VIII-Like 1 (NEIL1) (AA 200-390) protein (His tag)NEIL1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Endonuclease VIII-Like 1 (NEIL1) (AA 1-390) protein (His tag)NEIL1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Endonuclease VIII-Like 1 (NEIL1) (AA 1-390) protein (GST tag)NEIL1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Endonuclease VIII-Like 1 (NEIL1) (AA 2-390) protein (His tag)Crystallography grade NEIL1 Spezies: Human Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Endonuclease VIII-Like 1 (NEIL1) (AA 2-389) protein (His tag)Crystallography grade NEIL1 Spezies: Maus Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Endonuclease VIII-Like 1 (NEIL1) protein (Myc-DYKDDDDK Tag)NEIL1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Lagerung
- -80 °C,4 °C,-20 °C
- Informationen zur Lagerung
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- NEIL1 (Endonuclease VIII-Like 1 (NEIL1))
- Andere Bezeichnung
- NEIL1 (NEIL1 Produkte)
- Synonyme
- FPG1 Protein, NEI1 Protein, hFPG1 Protein, 2810450N13Rik Protein, Nei1 Protein, nei-like DNA glycosylase 1 Protein, nei like DNA glycosylase 1 Protein, nei endonuclease VIII-like 1 (E. coli) Protein, Neil1 Protein, NEIL1 Protein
- Hintergrund
- Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and roves damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the roved base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
- Molekulargewicht
- 59.6 kDa
- UniProt
- Q96FI4
- Pathways
- DNA Reparatur
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