FUS Protein (AA 136-608) (His-SUMO Tag)

Produktnummer ABIN5710740

Produktdetails

Target: FUS (Fused in Sarcoma (FUS))

Protein-Typ: Recombinant

Proteineigenschaft: AA 136-608

Spezies: Canine Distemper Virus (CDV)

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses FUS Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: QIHWDNLSTI GIIGTDNVHY KIMTRPSHQY LVIKLIPNAS LIENCTKAEL GEYEKLLNSV LEPINQALTL MTKNVKPLQS LGSGRRQRRF AGVVLAGVAL GVATAAQITA GIALHQSNLN AQAIQSLRTS LEQSNKAIEE IREATQETVI AVQGVQDYVN NELVPAMQHM SCELVGQRLG LRLLRYYTEL LSIFGPSLRD PISAEISIQA LIYALGGEIH KILEKLGYSG SDMIAILESR GIKTKITHVD LPGKFIILSI SYPTLSEVKG VIVHRLEAVS YNIGSQEWYT TVPRYIATNG YLISNFDESS CVFVSESAIC SQNSLYPMSP LLQQCIRGDT SSCARTLVSG TMGNKFILSK GNIVANCASI LCKCYSTSTI INQSPDKLLT FIASDTCPLV EIDGATIQVG GRQYPDMVYE GKVALGPAIS LDRLDVGTNL GNALKKLDDA KVLIDSSNQI LETVRRSSFN FGS

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: FUS (Fused in Sarcoma (FUS))

Andere Bezeichnung: FUS (FUS Produkte)

Synonyme: ALS6 Protein, ETM4 Protein, FUS1 Protein, HNRNPP2 Protein, POMP75 Protein, TLS Protein, D430004D17Rik Protein, D930039C12Rik Protein, Fus1 Protein, Tls Protein, FUS/TLS Protein, FUS RNA binding protein Protein, fused in sarcoma Protein, FUS Protein, Fus Protein

Substanzklasse: Viral Protein

Hintergrund: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell mbrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell mbranes. Directs fusion of viral and cellular mbranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell mbrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular mbrane, inducing the fusion between cell and virion mbranes. Later in infection, F proteins expressed at the plasma mbrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis .

Molekulargewicht: 67.5 kDa

UniProt: P12569