FUS Protein (AA 137-574) (His tag)
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- Target Alle FUS Proteine anzeigen
- FUS (Fused in Sarcoma (FUS))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 137-574
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Spezies
- Human respiratory syncytial virus B
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Quelle
- Hefe
- Aufreinigungstag / Konjugat
- Dieses FUS Protein ist gelabelt mit His tag.
- Applikation
- SDS-PAGE (SDS)
- Sequenz
- FLGFLLGVGS AIASGIAVSK VLHLEGEVNK IKNALLSTNK AVVSLSNGVS VLTSKVLDLK NYINNQLLPI VNQQSCRISN IETVIEFQQK NSRLLEINRE FSVNAGVTTP LSTYMLTNSE LLSLINDMPI TNDQKKLMSS NVQIVRQQSY SIMSIIKEEV LAYVVQLPIY GVIDTPCWKL HTSPLCTTNI KEGSNICLTR TDRGWYCDNA GSVSFFPQAD TCKVQSNRVF CDTMNSLTLP SEVSLCNTDI FNSKYDCKIM TSKTDISSSV ITSLGAIVSC YGKTKCTASN KNRGIIKTFS NGCDYVSNKG VDTVSVGNTL YYVNKLEGKN LYVKGEPIIN YYDPLVFPSD EFDASISQVN EKINQSLAFI RRSDELLHNV NTGKSTTNIM ITTIIIVIIV VLLSLIAIGL LLYCKAKNTP VTLSKDQLSG INNIAFSK
- Aufreinigung
- SDS-PAGE
- Reinheit
- > 90 %
- Top Product
- Discover our top product FUS Protein
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Lagerung
- -80 °C,4 °C,-20 °C
- Informationen zur Lagerung
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- FUS (Fused in Sarcoma (FUS))
- Andere Bezeichnung
- FUS (FUS Produkte)
- Synonyme
- ALS6 Protein, ETM4 Protein, FUS1 Protein, HNRNPP2 Protein, POMP75 Protein, TLS Protein, D430004D17Rik Protein, D930039C12Rik Protein, Fus1 Protein, Tls Protein, FUS/TLS Protein, FUS RNA binding protein Protein, fused in sarcoma Protein, FUS Protein, Fus Protein
- Substanzklasse
- Viral Protein
- Hintergrund
- During virus entry, induces fusion of viral and cellular mbranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma mbrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.
- Molekulargewicht
- 50.11 kDa
- UniProt
- O36634
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