KDM5A Protein (AA 437-603) (His-SUMO Tag)

Produktnummer ABIN5709797

Produktdetails

Target: KDM5A (Lysine (K)-Specific Demethylase 5A (KDM5A))

Protein-Typ: Recombinant

Proteineigenschaft: AA 437-603

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses KDM5A Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: EYALSGWNLN NMPVLEQSVL AHINVDISGM KVPWLYVGMC FSSFCWHIED HWSYSINYLH WGEPKTWYGV PSHAAEQLEE VMRELAPELF ESQPDLLHQL VTIMNPNVLM EHGVPVYRTN QCAGEFVVTF PRAYHSGFNQ GYNFAEAVNF CTADWLPIGR QCVNHYR

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: KDM5A (Lysine (K)-Specific Demethylase 5A (KDM5A))

Andere Bezeichnung: KDM5A (KDM5A Produkte)

Synonyme: Jarid1a Protein, JARID1A Protein, RBBP-2 Protein, RBBP2 Protein, RBP2 Protein, AA409370 Protein, C76986 Protein, Rbbp2 Protein, lysine demethylase 5A Protein, lysine (K)-specific demethylase 5A Protein, Kdm5a Protein, KDM5A Protein

Hintergrund: Histone dethylase that specifically dethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not dethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Dethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone dethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 .

Molekulargewicht: 35.3 kDa

UniProt: P29375

Pathways: Chromatin Binding, Warburg Effekt