Histone H3.3 Protein (AA 2-136) (His-SUMO Tag)

Produktnummer ABIN5709639

Produktdetails

Target: Histone H3.3

Protein-Typ: Recombinant

Proteineigenschaft: AA 2-136

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Histone H3.3 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: ARTKQTARKS TGGKAPRKQL ATKAARKSAP STGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFKT DLRFQSAAIG ALQEASEAYL VGLFEDTNLC AIHAKRVTIM PKDIQLARRI RGERA

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: Histone H3.3

Andere Bezeichnung: H33 (Histone H3.3 Produkte)

Synonyme: H3.3A Protein, H3F3 Protein, H3-IX Protein, H3-X Protein, H3.3B Protein, H3F3C Protein, H3F3B Protein, H3 histone family member 3A Protein, H3 histone, family 3A Protein, H3 histone, family 3B Protein, H3 histone, family 3C L homeolog Protein, histone H3.3 Protein, Histone H3.3 Protein, histone H3.3B-like Protein, H3F3A Protein, H3F3B Protein, H3f3a Protein, h3f3c.L Protein, LOC5567559 Protein, Bm1_29875 Protein, Bm1_40030 Protein, PTRG_03457 Protein, Phum_PHUM492720 Protein, UREG_07214 Protein, PAAG_07099 Protein, PITG_06950 Protein, PITG_06953 Protein, PITG_06955 Protein, LOC100361558 Protein, LOC100521680 Protein

Hintergrund: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacent throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a tplate. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome rodeling.

Molekulargewicht: 31.2 kDa

UniProt: P84243