COL4A1 Protein (AA 1445-1669) (His-SUMO Tag)

Produktnummer ABIN5709309

Produktdetails

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1445-1669

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses COL4A1 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: GFLVTRHSQT IDDPQCPSGT KILYHGYSLL YVQGNERAHG QDLGTAGSCL RKFSTMPFLF CNINNVCNFA SRNDYSYWLS TPEPMPMSMA PITGENIRPF ISRCAVCEAP AMVMAVHSQT IQIPPCPSGW SSLWIGYSFV MHTSAGAEGS GQALASPGSC LEEFRSAPFI ECHGRGTCNY YANAYSFWLA TIERSEMFKK PTPSTLKAGE LRTHVSRCQV CMRRT

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Andere Bezeichnung: CO4A1 (COL4A1 Produkte)

Synonyme: col4a1 Protein, wu:fc02g11 Protein, HANAC Protein, ICH Protein, POREN1 Protein, arresten Protein, Bru Protein, Col4a-1 Protein, Del(8)44H Protein, Raw Protein, Svc Protein, collagen, type IV, alpha 5 (Alport syndrome) Protein, collagen type IV alpha 1 chain Protein, collagen, type IV, alpha 1 Protein, col4a5 Protein, COL4A1 Protein, Col4a1 Protein

Hintergrund: Type IV collagen is the major structural component of glomerular basent mbranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Molekulargewicht: 40.9 kDa

UniProt: P02462

Pathways: Skeletal Muscle Fiber Development, Growth Factor Binding