FZD2 Protein (AA 24-190) (Fc Tag)

Produktnummer ABIN5674627

Produktdetails

Target: FZD2 (Frizzled Family Receptor 2 (FZD2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-190

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FZD2 Protein ist gelabelt mit Fc Tag.

Sequenz: AA 24-190

Produktmerkmale: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.6 kDa. The protein migrates as 32 kDa, 35 kDa, 37 kDa, 40 kDa, 45 kDa and 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Antigendetails

Target: FZD2 (Frizzled Family Receptor 2 (FZD2))

Andere Bezeichnung: Frizzled-2 (FZD2 Produkte)

Synonyme: BG01711 Protein, CG9739 Protein, D-Fz2 Protein, D-fz2 Protein, DFZ2 Protein, DFz-2 Protein, DFz2 Protein, Dfrz2 Protein, Dfz2 Protein, Dfz[[2]] Protein, Dm Fz2 Protein, Dmel\\CG9739 Protein, FZ2 Protein, Fz2 Protein, dFz2 Protein, dfz(2) Protein, dfz2 Protein, dfz2r Protein, frz2 Protein, fz-2 Protein, fz8 Protein, zfz2 Protein, zg08 Protein, cb383 Protein, wu:fb70g09 Protein, FZD2 Protein, fzE2 Protein, hFz2 Protein, Fz-10 Protein, Fzd10 Protein, cFz-2 Protein, frizzled2 Protein, fz2 Protein, xfz2 Protein, AL033370 Protein, AW456835 Protein, Fz10 Protein, Mfz10 Protein, Mfz10a Protein, frizzled 2 Protein, frizzled class receptor 2 Protein, frizzled class receptor 2 S homeolog Protein, fz2 Protein, fzd2 Protein, FZD2 Protein, Fzd2 Protein, fzd2.S Protein

Hintergrund: Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Molekulargewicht: 44.4 kDa

Pathways: WNT Signalweg