Glucagon Protein (GCG) (AA 1-180) (His tag)

Produktnummer ABIN4370442

Produktdetails

Target: Glucagon (GCG)

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-180

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses Glucagon Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Glucagon/GCG (C-6His)

Sequenz: RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK

Produktmerkmale: Recombinant Human Glucagon/GCG is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Met1-Lys180) of Human Glucagon fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,200 mM NaCl,1 mM DTT,50 % Glycerol, pH 8.0.

Konservierungsmittel: Dithiothreitol (DTT)

Vorsichtsmaßnahmen: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: -80 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: Glucagon (GCG)

Andere Bezeichnung: Glucagon (GCG Produkte)

Synonyme: GLP1 Protein, GLP2 Protein, GRPP Protein, GLP-1 Protein, Glu Protein, PPG Protein, GCG Protein, gcg-A Protein, gcg1 Protein, glucagon Protein, glucagon L homeolog Protein, GCG Protein, Gcg Protein, gcg.L Protein

Sub Type: Fusionprotein

Hintergrund: Glucagon is a secreted protein and belongs to the glucagon family. Glucagon can be cleved into 8 chains, playing an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon can regulates blood glucose by decreasing glycolysis and increasing gluconeogenesis. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.
Alternative Names: Glucagon, Glicentin, Glicentin-Related Polypeptide, GRPP, Oxyntomodulin, OXM, OXY, Glucagon, Glucagon-Like Peptide 1, GLP-1, Incretin Hormone, Glucagon-like Peptide 1, GLP-1, Glucagon-Like Peptide 2, GLP-2, GCG

Molekulargewicht: 18.6 kDa

UniProt: P01275

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling