Neuregulin 4 Protein (NRG4) (AA 2-62) (His tag)
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- Target Alle Neuregulin 4 (NRG4) Proteine anzeigen
- Neuregulin 4 (NRG4)
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 2-62
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses Neuregulin 4 Protein ist gelabelt mit His tag.
- Sequenz
- AA 2-62
- Produktmerkmale
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 8.6 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Reinheit
- >90 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product NRG4 Protein
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Neuregulin 4 (NRG4) (AA 1-115) protein (GST tag)
NRG4 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Neuregulin 4 (NRG4) (AA 1-61) protein (His tag)NRG4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Neuregulin 4 (NRG4) (Active) proteinNRG4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Neuregulin 4 (NRG4) (AA 1-115) protein (Strep Tag)Crystallography grade NRG4 Spezies: Human Wirt: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Neuregulin 4 (NRG4) (AA 1-115) protein (Strep Tag)Crystallography grade NRG4 Spezies: Maus Wirt: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Neuregulin 4 (NRG4) (AA 1-61) protein (rho-1D4 tag)Crystallography grade NRG4 Spezies: Human Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Neuregulin 4 (NRG4) (AA 1-61) protein (rho-1D4 tag)Crystallography grade NRG4 Spezies: Maus Wirt: Insektenzellen Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM NaCl, pH 7.5
- Handhabung
- Please avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
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- Target
- Neuregulin 4 (NRG4)
- Andere Bezeichnung
- Neuregulin-4 (NRG4 Produkte)
- Synonyme
- HRG4 Protein, AI552600 Protein, neuregulin 4 Protein, NRG4 Protein, Nrg4 Protein, LOC100347220 Protein
- Hintergrund
- Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival. The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation. Furthermore, NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
- Molekulargewicht
- 8.6 kDa
- UniProt
- Q8WWG1
- Pathways
- RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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