p130 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2730602

Produktdetails

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses p130 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human RBL2 / p130 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))

Andere Bezeichnung: Rbl2,p130 (RBL2 Produkte)

Synonyme: RBL2 Protein, RBR2 Protein, RRB2a Protein, PRB2 Protein, RBR-2 Protein, Rb2 Protein, p130 Protein, P130 Protein, retinoblastoma-like 2 (p130) Protein, RB transcriptional corepressor like 2 Protein, related to retinoblastoma 2 Protein, RBL2 Protein, LOC541652 Protein, Rbl2 Protein

Hintergrund: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. [UniProtKB/Swiss-Prot Function]

Molekulargewicht: 128.2 kDa

NCBI Accession: NP_005602

Pathways: Zellzyklus, Mitotic G1-G1/S Phases