PEN2 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2728653

Produktdetails

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PEN2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human PEN2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Andere Bezeichnung: Pen2 (PSENEN Produkte)

Synonyme: MSTP064 Protein, PEN-2 Protein, PEN2 Protein, Psenen Protein, ACYPI006208 Protein, 1700023M09Rik Protein, Pen-2 Protein, RGD1312037 Protein, CG33198 Protein, Dmel\\CG33198 Protein, anon-AE003800.1 Protein, dPen-2 Protein, psenen Protein, pen-2 Protein, pen2 Protein, zgc:109727 Protein, presenilin enhancer gamma-secretase subunit Protein, presenilin enhancer 2 Protein, presenilin enhancer gamma secretase subunit Protein, Gamma-secretase subunit pen-2 Protein, presenilin enhancer Protein, presenilin enhancer gamma secretase subunit S homeolog Protein, PSENEN Protein, PEN2 Protein, Psenen Protein, pen-2 Protein, psenen.S Protein, psenen Protein

Hintergrund: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer&aposs disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.

Molekulargewicht: 11.8 kDa

NCBI Accession: NP_758844

Pathways: Notch Signalweg, Neurotrophin Signalübertragung