PANK2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2728205

Produktdetails

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 1

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PANK2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human PANK2 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Andere Bezeichnung: Pank2 (PANK2 Produkte)

Synonyme: ATPANK2 Protein, F10M6.180 Protein, F10M6_180 Protein, pantothenate kinase 2 Protein, PANK2 Protein, C20orf48 Protein, HARP Protein, HSS Protein, NBIA1 Protein, PKAN Protein, 4933409I19Rik Protein, AI642621 Protein, pantothenate kinase 2 Protein, pantothenate kinase 2, mitochondrial Protein, ribonuclease A family member 11 (inactive) Protein, PANK2 Protein, Tsp_01576 Protein, LOC100539295 Protein, Pank2 Protein, RNASE11 Protein

Hintergrund: This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.

Molekulargewicht: 59.1 kDa

NCBI Accession: NP_705902

Pathways: Ribonucleoside Biosynthetic Process