PANK2 Produkte
(Pantothenate Kinase 2 (PANK2))
Kategorien
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008].
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Ausgewählte PANK2 Kategorien
PANK2 Antikörper
High quality antibodies with extensive validation data.
PANK2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PANK2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Dog, Human, Monkey, Rat
Applikation
WB, IHC, IF, IHC (p), FACS
Validierungen
- (8)
Kat. Nr.
ABIN1500026
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF
Validierungen
- (3)
Kat. Nr.
ABIN7162603
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN566414
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene PANK2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6206931
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PANK2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN3013381
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3085454
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7421605
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PANK2 Produkten
: "Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients." in: Neurobiology of disease, (2015) (PubMed).: "Glycyrrhizin suppresses lung adenocarcinoma cell growth through inhibition of thromboxane synthase." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 33, Issue 2, pp. 375-88, (2014) (PubMed).
: "DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis." in: The Journal of cell biology, Vol. 206, Issue 2, pp. 183-97, (2014) (PubMed).
: "Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 41, Issue 8, pp. 1505-13, (2013) (PubMed).
: "Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model." in: Human molecular genetics, Vol. 21, Issue 24, pp. 5294-305, (2012) (PubMed).
: "An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria." in: Human molecular genetics, Vol. 12, Issue 3, pp. 321-7, (2003) (PubMed).
: "Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic." in: Neurology, Vol. 61, Issue 10, pp. 1423-6, (2003) (PubMed).
: "HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration." in: Neurology, Vol. 58, Issue 11, pp. 1673-4, (2002) (PubMed).
Synonyme und alternative Namen zu PANK2
pantothenate kinase 2 (PANK2), pantothenate kinase 2 (Tsp_01576), pantothenate kinase 2, mitochondrial (LOC100539295), pantothenate kinase 2 (Pank2), ribonuclease A family member 11 (inactive) (RNASE11), 4933409I19Rik, AI642621, ATPANK2, C20orf48, F10M6.180, F10M6_180, HARP, HSS, NBIA1, PANK2, pantothenate kinase 2, PKANBezeichner auf Proteinebene für PANK2
- pantothenate kinase 2 (Hallervorden-Spatz syndrome)
- pantothenate kinase 2
- pantothenate kinase 2, mitochondrial-like
- Hallervorden-Spatz syndrome
- pantothenate kinase 2, mitochondrial
- pantothenic acid kinase 2
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