OAS1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Target Alle OAS1 Proteine anzeigen
- OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- Transcript Variant 2
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses OAS1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
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- Recombinant human OAS1 / OIAS (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Reinheit
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product OAS1 Protein
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- Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
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The tag is located at the C-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
- Andere Bezeichnung
- Oas1,oias (OAS1 Produkte)
- Synonyme
- OAS1 Protein, IFI-4 Protein, OIAS Protein, OIASI Protein, L3 Protein, Pp2a2 Protein, 2',5'-oligoadenylate synthetase 1 Protein, 2'-5'-oligoadenylate synthetase 1 Protein, 2'-5' oligoadenylate synthetase 1A Protein, protein phosphatase 2 catalytic subunit beta Protein, OAS1 Protein, Oas1a Protein, Ppp2cb Protein, Oas1 Protein
- Hintergrund
- This gene is induced by interferons and encodes a protein that synthesizes 2&apos,5&apos-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12.
- Molekulargewicht
- 41.6 kDa
- NCBI Accession
- NP_002525
- Pathways
- Hepatitis C
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