NR1H2 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2727542

Produktdetails

Target: NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NR1H2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human NR1H2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: NR1H2 (Nuclear Receptor Subfamily 1, Group H, Member 2 (NR1H2))

Andere Bezeichnung: Nr1h2 (NR1H2 Produkte)

Synonyme: NR1H2 Protein, lxr-b Protein, lxrb Protein, ner Protein, ner-i Protein, rip15 Protein, unr Protein, DKFZp468A0622 Protein, AI194859 Protein, LXR Protein, LXRB Protein, LXRbeta Protein, NER1 Protein, OR-1 Protein, RIP15 Protein, UR Protein, Unr Protein, Unr2 Protein, LXR-b Protein, NER Protein, NER-I Protein, UNR Protein, nuclear receptor subfamily 1 group H member 2 Protein, nuclear receptor subfamily 1, group H, member 2 Protein, nuclear receptor subfamily 1 group H member 2 L homeolog Protein, NR1H2 Protein, nr1h2 Protein, Nr1h2 Protein, nr1h2.L Protein

Hintergrund: The liver X receptors, LXRA (NR1H3 MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010].

Molekulargewicht: 50.9 kDa

NCBI Accession: NP_009052

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding