IDE Protein (Transcript Variant 1) (His tag)
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- Target Alle IDE Proteine anzeigen
- IDE (Insulin-Degrading Enzyme (IDE))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- Transcript Variant 1
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses IDE Protein ist gelabelt mit His tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
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- Recombinant human Insulin-degrading enzyme (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Reinheit
- > 95 % as determined by SDS-PAGE and Coomassie blue staining
- Endotoxin-Niveau
- Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
- Top Product
- Discover our top product IDE Protein
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- Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
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The tag is located at the C-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- Supplied as a 0.2 μM filtered solution of 20 mM PB,150 mM NaCl, pH 7.4
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- IDE (Insulin-Degrading Enzyme (IDE))
- Andere Bezeichnung
- Insulin-Degrading Enzyme (IDE Produkte)
- Synonyme
- zgc:162603 Protein, IDE Protein, 1300012G03Rik Protein, 4833415K22Rik Protein, AA675336 Protein, AI507533 Protein, INSDEGM Protein, INSULYSIN Protein, insulin degrading enzyme Protein, insulin-degrading enzyme Protein, metallopeptidase Protein, IDE Protein, ide Protein, LOC591315 Protein, CC1G_01115 Protein, Bm1_26615 Protein, PTRG_10875 Protein, SJAG_01430 Protein, EBI_21700 Protein, VDBG_06702 Protein, LOAG_08082 Protein, PGTG_04982 Protein, Tsp_00424 Protein, Ide Protein
- Hintergrund
- This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
- Molekulargewicht
- 41.27kD
- NCBI Accession
- NP_004960
- Pathways
- SARS-CoV-2 Protein Interaktom
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