HLA-DMB Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2722839

Produktdetails

Target: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses HLA-DMB Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human HLA class II DM beta / HLA-DMB protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Andere Bezeichnung: Hla Class II Dm Beta,hla-Dmb (HLA-DMB Produkte)

Synonyme: RING7 Protein, D6S221E Protein, RT1.DMb Protein, RT1.Mb Protein, MHC-DMB Protein, major histocompatibility complex, class II, DM beta Protein, RT1 class II, locus DMb Protein, HLA-DMB Protein, RT1-DMb Protein, PATR-DMB Protein

Hintergrund: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Molekulargewicht: 27.1 kDa

NCBI Accession: NP_002109

Pathways: Cancer Immune Checkpoints