GCH1 Protein (His tag)
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- Target Alle GCH1 Proteine anzeigen
- GCH1 (GTP Cyclohydrolase 1 (GCH1))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses GCH1 Protein ist gelabelt mit His tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
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- Recombinant human GTP cyclohydrolase 1 (GCH1) (full length, N-term HIS tag, transcript variant 2) protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Reinheit
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product GCH1 Protein
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- Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
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The tag is located at the N-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 50 μg/mL
- Buffer
- 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- GCH1 (GTP Cyclohydrolase 1 (GCH1))
- Abstract
- GCH1 Produkte
- Synonyme
- DYT14 Protein, DYT5 Protein, DYT5a Protein, GCH Protein, GTP-CH-1 Protein, GTPCH1 Protein, HPABH4B Protein, GTP-CH Protein, GTPCH Protein, Gch Protein, MGC89622 Protein, gch1a Protein, wu:fc16b10 Protein, zgc:195269 Protein, GTP cyclohydrolase 1 Protein, GTP cyclohydrolase 1-like Protein, GCH1 Protein, Gch1 Protein, gch1 Protein, Weevi_1190 Protein, Halhy_0838 Protein, Sinme_1220 Protein, Sphch_1077 Protein, LOC100136794 Protein
- Hintergrund
- This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described however, not all variants give rise to a functional enzyme.
- Molekulargewicht
- 27.7 kDa
- NCBI Accession
- NP_001019195
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