Geminin Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2721810

Produktdetails

Target: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Geminin Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Geminin protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Andere Bezeichnung: Geminin (GMNN Produkte)

Synonyme: CG3183 Protein, Dm Geminin Protein, Dm geminin Protein, Dmel\\CG3183 Protein, Gem Protein, Geminin Protein, anon-WO0257455.1 Protein, gem Protein, l(2)k14019 Protein, v(2)k09107 Protein, sb:cb254 Protein, zgc:66217 Protein, GB16871 Protein, GMNN Protein, geminin Protein, dyak_GLEANR_833 Protein, DyakGE24654 Protein, GE24654 Protein, LOC100049517 Protein, AW546347 Protein, geminin, DNA replication inhibitor Protein, CG3183 gene product from transcript CG3183-RA Protein, geminin Protein, GE24654 gene product from transcript GE24654-RA Protein, GMNN Protein, geminin Protein, gmnn Protein, LOC410093 Protein, Dyak\geminin Protein, Gmnn Protein

Hintergrund: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

Molekulargewicht: 23.4 kDa

NCBI Accession: NP_056979

Pathways: EGFR Signaling Pathway, DNA Replication