HSD11B1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Target Alle HSD11B1 Proteine anzeigen
- HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- Transcript Variant 2
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses HSD11B1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
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- Recombinant human 11-beta HSD1 / HSD11B1 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Reinheit
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product HSD11B1 Protein
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- Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
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The tag is located at the C-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
- Andere Bezeichnung
- 11-beta Hsd1,hsd11b1 (HSD11B1 Produkte)
- Synonyme
- 11-DH Protein, 11-beta-HSD1 Protein, CORTRD2 Protein, HDL Protein, HSD11 Protein, HSD11B Protein, HSD11L Protein, SDR26C1 Protein, hsd11 Protein, hsd11b Protein, LRRGT00065 Protein, hydroxysteroid 11-beta dehydrogenase 1 Protein, hydroxysteroid (11-beta) dehydrogenase 1b Protein, hydroxysteroid (11-beta) dehydrogenase 1 L homeolog Protein, HSD11B1 Protein, HSD11B1b Protein, hsd11b1.L Protein, Hsd11b1 Protein
- Hintergrund
- The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
- Molekulargewicht
- 32.2 kDa
- NCBI Accession
- NP_861420
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process
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