ARNTL Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2714935

Produktdetails

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 3

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ARNTL Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human ARNTL / BMAL1 (transcript variant 3) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Andere Bezeichnung: Arntl,bmal1 (ARNTL Produkte)

Synonyme: BMAL1 Protein, BMAL1c Protein, JAP3 Protein, MOP3 Protein, PASD3 Protein, TIC Protein, bHLHe5 Protein, Bmal1 Protein, ARNTL Protein, xBmal1 Protein, arntl Protein, Arnt3 Protein, BMAL1b Protein, bmal1b' Protein, aryl hydrocarbon receptor nuclear translocator like Protein, aryl hydrocarbon receptor nuclear translocator-like Protein, aryl hydrocarbon receptor nuclear translocator like S homeolog Protein, ARNTL Protein, Arntl Protein, arntl.S Protein, arntl Protein

Hintergrund: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 64 kDa

NCBI Accession: NP_001025444

Pathways: Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Warburg Effekt