CDK8 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2713871

Produktdetails

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CDK8 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human CDK8 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Andere Bezeichnung: Cdk8 (CDK8 Produkte)

Synonyme: K35 Protein, wu:fk95h11 Protein, cyclin dependent kinase 8 Protein, cyclin-dependent kinase 8 Protein, cyclin-dependent kinase 8 S homeolog Protein, Cyclin-dependent kinase 8 Protein, cyclin dependent kinase 19 Protein, CDK8 Protein, Cdk8 Protein, cdk8 Protein, cdk8.S Protein, cdk-8 Protein, CDK19 Protein

Hintergrund: This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 53.1 kDa

NCBI Accession: NP_001251

Pathways: Zellzyklus, Regulation of Lipid Metabolism by PPARalpha