ERCC5 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2712283

Produktdetails

Target: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ERCC5 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human ERCC5 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: ERCC5 (DNA Repair Protein Complementing XP-G Cells (ERCC5))

Andere Bezeichnung: Ercc5 (ERCC5 Produkte)

Synonyme: COFS3 Protein, ERCM2 Protein, UVDR Protein, XPG Protein, XPGC Protein, cofs3 Protein, ercm2 Protein, uvdr Protein, xpg Protein, xpgc Protein, Xpg Protein, ERCC excision repair 5, endonuclease Protein, excision repair cross-complementation group 5 L homeolog Protein, excision repair cross-complementing rodent repair deficiency, complementation group 5 Protein, ERCC5 Protein, ercc5.L Protein, Ercc5 Protein

Hintergrund: This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

Molekulargewicht: 133.1 kDa

NCBI Accession: NP_000114

Pathways: DNA Reparatur