ATG12 Protein (AA 101-141) (His tag)

Produktnummer ABIN2468250

Produktdetails

Target: ATG12 (Autophagy Related 12 (ATG12))

Protein-Typ: Recombinant

Proteineigenschaft: AA 101-141

Spezies: Human, Maus

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses ATG12 Protein ist gelabelt mit His tag.

Applikation: ELISA, Western Blotting (WB), Mass Spectrometry (MS), Neutralization (Neut)

Reinheit: ~95 %

Anwendungsinformationen

Applikationshinweise: This recombinant protein can be used for WB, ELISA, MS and neutralization assays.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1X PBS containing 0.1 % SDS

Handhabung: Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Lagerung: -80 °C

Informationen zur Lagerung: Store in working aliquots at -70 °C.

Antigendetails

Target: ATG12 (Autophagy Related 12 (ATG12))

Andere Bezeichnung: ATG12 (ATG12 Produkte)

Synonyme: APG12 Protein, APG12L Protein, FBR93 Protein, HAPG12 Protein, Apg12l Protein, AUTOPHAGY 12 Protein, AUTOPHAGY 12 B Protein, CG10861 Protein, Dmel\\CG10861 Protein, atg12 Protein, ATG12 Protein, apg12 Protein, DDBDRAFT_0185323 Protein, DDBDRAFT_0191412 Protein, DDB_0185323 Protein, DDB_0191412 Protein, 4931423H11Rik Protein, A330058M13Rik Protein, Atg12l Protein, AO090001000593 Protein, autophagy related 12 Protein, Ubiquitin-like superfamily protein Protein, Atg12p Protein, autophagy protein Protein, ubiquitin-like protein ATG12B Protein, autophagy associated protein Atg12 Protein, Autophagy-related 12 Protein, ATG12 autophagy related 12 homolog (S. cerevisiae) Protein, ATG12 autophagy related 12 homolog (S. cerevisiae) pseudogene Protein, autophagy associated ubiquitin-like modifier Atg12 Protein, hypothetical protein Protein, Autophagy-related protein 12 (Autophagy-related ubiquitin-like modifier ATG12) Protein, autophagy protein 12 Protein, autophagy related 12 S homeolog Protein, autophagy-related protein 12 Protein, ATG12 Protein, Atg12 Protein, APG12B Protein, APG12 Protein, LOC9321066 Protein, apg12 Protein, atg12 Protein, LOC743425 Protein, CAALFM_C113950CA Protein, atg12.S Protein, ANI_1_922094 Protein, AOR_1_1064164 Protein

Hintergrund: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2). This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1 (3). ATG12, another member of the autophagy protein family, forms a conjugate with ATG5 , this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy (4). This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells (5). ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7 (6).

Molekulargewicht: 10 kDa (Calculated)

Gen-ID: 9140

OMIM: 17366729

UniProt: O94817, Q9CQY1

Pathways: Autophagie