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V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 26-651) protein (Fc Tag)

ERBB4 Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Produktnummer ABIN2181046
$286.00
Zzgl. Versandkosten $45.00
Lieferung in 2 bis 3 Werktagen
  • Target Alle ERBB4 Proteine anzeigen
    ERBB4
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 26-651
    Spezies
    • 16
    • 5
    • 3
    Human
    Quelle
    • 10
    • 5
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses ERBB4 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 26-651
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 96 kDa. The protein migrates as 122-132 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >90 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Target
    ERBB4
    Andere Bezeichnung
    ErbB4 (ERBB4 Produkte)
    Synonyme
    erbb4, si:ch211-227n20.1, Her4, c-erbB-4, HER4, p180erbB4, erb-b2 receptor tyrosine kinase 4, erb-b2 receptor tyrosine kinase 4a, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), erb-b2 receptor tyrosine kinase 4 L homeolog, receptor tyrosine-protein kinase ErbB-4, ERBB4, erbb4a, erbb4, erbb4.L, Tsp_13582, Erbb4
    Hintergrund
    Receptor tyrosine-protein kinase erbB-4 (ErbB4) is also known as Her4, is a single-pass type I transmembrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB4 is expressed in normal skeletal muscle, heart, pituitary, brain and several breast carcinomas. ERBB4 contains multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. ErbB4 appears to play important roles in neuronal development, development of the heart and cancer. ERBB4 has been shown to interact with: DLG4, NRG1, STAT5A and YAP1. Mutations in this gene have been associated with cancer. Other single-nucleotide polymorphisms and a risk haplotype have been linked to schizophrenia.
    Molekulargewicht
    96.0 kDa
    NCBI Accession
    NP_005226
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
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