APOA1 Protein (AA 19-267) (His tag)

Produktnummer ABIN2180599

Produktdetails

Target: APOA1 (Apolipoprotein A-I (APOA1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 19-267

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses APOA1 Protein ist gelabelt mit His tag.

Sequenz: AA 19-267

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.8 kDa. The protein migrates as 26-30 kDa under reducing (R) condition (SDS-PAGE).

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.

Antigendetails

Target: APOA1 (Apolipoprotein A-I (APOA1))

Andere Bezeichnung: Apo-A1 (APOA1 Produkte)

Synonyme: Alp-1 Protein, Apoa-1 Protein, Brp-14 Protein, Ltw-1 Protein, Lvtw-1 Protein, Sep-1 Protein, Sep-2 Protein, Sep2 Protein, apoA-I Protein, apoa Protein, apoa1 Protein, cb49 Protein, wu:fb33f01 Protein, zgc:103718 Protein, MGC64335 Protein, MGC89745 Protein, Apo-AI Protein, ApoA-I Protein, APOA1 Protein, LOC100136573 Protein, apoa-i Protein, ApoAI Protein, apolipoprotein A1 Protein, apolipoprotein A-I Protein, apolipoprotein A-Ia Protein, apolipoprotein A-I S homeolog Protein, apolipoprotein A4 Protein, APOA1 Protein, Apoa1 Protein, apoa1a Protein, apoa1.S Protein, apoa1 Protein, LOC100136573 Protein, apoa-i Protein, apoa4 Protein

Hintergrund: ApoA1 is also known as apolipoprotein A-I, ApoA-I , and is the major protein component of high density lipoprotein (HDL) in plasma. It has a specific role in lipid metabolism. Chylomicrons secreted from the intestinal enterocyte also contain ApoA1 but it is quickly transferred to HDL in the bloodstream. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. In addition, it has been shown that ApoA1 is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.

Molekulargewicht: 29.8 kDa

NCBI Accession: NP_000030

Pathways: Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism