Cardiotrophin 1 Protein (CTF1) (AA 2-203)

Produktnummer ABIN2017713

Produktdetails

Target: Cardiotrophin 1 (CTF1)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 2-203

Spezies: Maus

Quelle: HEK-293T Cells

Produktmerkmale: The EC50 value of Mouse Cardiotrophin-1 determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.25 ng/mL, corresponding to a specific activity of ≥ 0.8 x 10^6 units/mg.

Reinheit: > 95 % as analyzed by SDS-PAGE.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant Mouse Cardiotrophin-1 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Mouse Cardiotrophin-1 should be stable up to 1 week at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: Cardiotrophin 1 (CTF1)

Andere Bezeichnung: Cardiotrophin-1(CT-1) (CTF1 Produkte)

Synonyme: CTF1 Protein, ct1 Protein, ct-1 Protein, ctf2 Protein, CT-1 Protein, CT1 Protein, cardiotrophin 1 Protein, cardiotrophin-1 Protein, CTF1 Protein, ctf1 Protein, Ctf1 Protein, LOC100736818 Protein

Hintergrund: Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). CT-1 is associated with the pathophysiology of several types of heart disease including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF-kappaB DNA -binding activities. CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine.Recombinant mouse Cardiotrophin-1 produced in HEK293 cells is a polypeptide chain containing 202 amino acids. A fully biologically active molecule, rmCT-1 has a molecular mass of 22-27 kDa analyzed by reducing SDS-PAGE.
Synonyms: CTF1, CT-1

Molekulargewicht: 22-27 kDa, observed by reducing SDS-PAGE.

UniProt: Q60753

Pathways: JAK-STAT Signalweg