Betacellulin Protein (BTC) (AA 32-111)

Produktnummer ABIN2017690

Produktdetails

Target: Betacellulin (BTC)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 32-111

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Produktmerkmale: ED50 <0.5 ng/mL, measured by a cell proliferation assay using3T3cells, corresponding to a specific activity of>2× 10^6 units/mg.
AA 32-111, expressed with an N-terminal Met.

Reinheit: > 95 % by SDS-PAGE analysis.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against 50 mM Tris, 300 mM NaCl, pH 9.0.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant mouse Betacellulin (rmBetacellulin) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmBetacellulin remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: Betacellulin (BTC)

Andere Bezeichnung: Betacellulin (BTC Produkte)

Synonyme: BTC Protein, LOC100228121 Protein, probetacellulin Protein, Bcn Protein, betacellulin Protein, betacellulin, epidermal growth factor family member Protein, BTC Protein, LOC100228121 Protein, Btc Protein

Hintergrund: Betacellulin is a pleiotropic cytokine that belongs to the Epidermal Growth Factor (EGF) family. Like other members of the EGF family, Betacellulin possesses a conserved sequence of 35-40 amino acids which contain 3 disulfide bonds formed by 6 cysteines. Betacellulin is unique in the EGF family since it can bind and activate a broad spectrum of ErbB receptors. Functionally, Betacellulin plays a role in the development of the pancreas by activating signaling pathways beneficial for the function, survival and regeneration of pancreatic beta-cells. Additionally, Betacellulin has potential angiogenic activities and is important for the growth, development and repair of certain tissues.Recombinant mouse Betacellulin (rmBetacellulin) produced in E. coli is a single non-glycosylated polypeptide chain containing 81 amino acids. A fully biologically active molecule, rmBetacellulin has a molecular mass of 9.2 kDa analyzed by reducing SDS-PAGE.
Synonyms: BTC

Molekulargewicht: 9.2 kDa, observed by reducing SDS-PAGE.

UniProt: Q05928

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung