TNFSF18 Protein (AA 74-198)

Produktnummer ABIN2017653

Produktdetails

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 74-198

Spezies: Human

Quelle: Escherichia coli (E. coli)

Produktmerkmale: ED50 < 5 ng/mL, measured by the amount of Interleukin-8 produced by PMBC, corresponding to a specific activity of > 2.0 x 10^5 units/mg.
AA 74-198, expressed with an N-terminal Met.

Reinheit: > 95 % by SDS-PAGE analysis.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against 50 mM Tris, pH 8.0.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant human Activation-Inducible TNF-Related Ligand (rhAITRL) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhAITRL remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Andere Bezeichnung: Activation-Inducible TNF-Related Ligand (AITRL) (TNFSF18 Produkte)

Synonyme: Gitrl Protein, AITRL Protein, GITRL Protein, TL6 Protein, hGITRL Protein, TNLG2A Protein, tumor necrosis factor (ligand) superfamily, member 18 Protein, TNF superfamily member 18 Protein, Tnfsf18 Protein, TNFSF18 Protein

Hintergrund: Activation-Inducible TNF-Related Ligand (AITRL), also known as Glucocorticoid-Induced TNF-Related Ligand (GITRL), belongs to the tumor necrosis factor superfamily (TNFSF). AITRL is a Type II single transmembrane protein and shares low conservation within the extracellular domain with other TNFSF members. AITRL is expressed on macrophages, immature and mature dendritic cells and B cells. Its receptor, Activation-Inducible TNFR family Receptor (AITR), is expressed on T lymphocytes, natural killer (NK) cells, and antigen-presenting cells. Upon binding by AITRL, AITR can be released. AITR activation increases resistance to tumors and viral infections and is involved in autoimmune and inflammatory processes. In addition, activated AITR increases TCR-induced T cell proliferation and cytokine production and rescues T cells and NK cells from apoptosis. Recombinant human Activation-Inducible TNF-Related Ligand (rhAITRL) produced in E. coli is a single non-glycosylated polypeptide chain containing 126 amino acids. A fully biologically active molecule, rhAITRL has a molecular mass of 14.3 kDa analyzed by reducing SDS-PAGE.
Synonyms: Activation-induced TNFR member Ligand, TNFSF18, GITRL, TL-6

Molekulargewicht: 14.3 kDa, observed by reducing SDS-PAGE.

UniProt: Q9UNG2