Lipocalin 2 Protein (LCN2) (AA 21-198) (His tag)

Produktnummer ABIN1945611

Produktdetails

Target: Lipocalin 2 (LCN2)

Protein-Typ: Recombinant

Proteineigenschaft: AA 21-198

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses Lipocalin 2 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human NGAL/Lipocalin-2/LCN2 (C-6His, Human Cells)

Sequenz: QDSTSDLIPA PPLSKVPLQQ NFQDNQFQGK WYVVGLAGNA ILREDKDPQK MYATIYELKE DKSYNVTSVL FRKKKCDYWI RTFVPGCQPG EFTLGNIKSY PGLTSYLVRV VSTNYNQHAM VFFKKVSQNR EYFKITLYGR TKELTSELKE NFIRFSKSLG LPENHIVFPV PIDQCIDGVD HHHHHH

Produktmerkmale: Recombinant Human LCN2 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (AA 21-198) of Human LCN2 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of PBS, 50 % glycerol, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: -80 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: Lipocalin 2 (LCN2)

Andere Bezeichnung: LCN2 (LCN2 Produkte)

Synonyme: LCN2 Protein, 24p3 Protein, MSFI Protein, NGAL Protein, AW212229 Protein, Sip24 Protein, lipocalin 2 Protein, LCN2 Protein, Lcn2 Protein

Hintergrund: LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. LCN2 is involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Molekulargewicht: 21.6 kDa

UniProt: P80188

Pathways: Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis