TNFSF18 Protein (AA 45-173, Extracellular Domain, Soluble) (DYKDDDDK Tag)

Produktnummer ABIN1344404

Produktdetails

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: Soluble, Extracellular Domain, AA 45-173

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses TNFSF18 Protein ist gelabelt mit DYKDDDDK Tag.

Applikation: SDS-PAGE (SDS)

Spezifität: Binds to mouse GITR.

Kreuzreaktivität: Maus

Produktmerkmale: The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.

Reinheit: >90 % (SDS-PAGE)

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: <0.1EU/μg purified protein (LAL test, Lonza).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Induces GITR-mediated NF-kappaB activation in HEK 293 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.2μm-filtered solution in 10 mM glycine, pH 10.0.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C.

Haltbarkeit: 3 months

Antigendetails

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Andere Bezeichnung: GITRL (TNFSF18 Produkte)

Synonyme: Gitrl Protein, AITRL Protein, GITRL Protein, TL6 Protein, hGITRL Protein, TNLG2A Protein, tumor necrosis factor (ligand) superfamily, member 18 Protein, TNF superfamily member 18 Protein, Tnfsf18 Protein, TNFSF18 Protein

Hintergrund: GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Molekulargewicht: ~22kDa (SDS-PAGE)

UniProt: Q7TS55