Kallikrein 7 Protein (KLK7) (AA 23-252) (His tag)

Produktnummer ABIN1097020

Produktdetails

Target: Kallikrein 7 (KLK7)

Protein-Typ: Recombinant

Proteineigenschaft: AA 23-252

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses Kallikrein 7 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Kallikrein 7/KLK7/SCEE (C-6His

Sequenz: EEAQGDKIID GAPCARGSHP WQVALLSGNQ LHCGGVLVNE RWVLTAAHCK MNEYTVHLGS DTLGDRRAQR IKASKSFRHP GYSTQTHVND LMLVKLNSQA RLSSMVKKVR LPSRCEPPGT TCTVSGWGTT TSPDVTFPSD LMCVDVKLIS PQDCTKVYKD LLENSMLCAG IPDSKKNACN GDSGGPLVCR GTLQGLVSWG TFPWGQPNDP GVYTQVCKFT KWINDTMKKH VDHHHHHH

Produktmerkmale:

Recombinant Human Kallikrein 7/KLK7/SCEE (C-6His

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM HEPES, 150 mM NaCl, pH 7.5.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: -80 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: Kallikrein 7 (KLK7)

Andere Bezeichnung: Kallikrein 7 (KLK7 Produkte)

Synonyme: Prss6 Protein, SCCE Protein, PRSS6 Protein, hK7 Protein, kallikrein related-peptidase 7 (chymotryptic, stratum corneum) Protein, kallikrein-related peptidase 7 Protein, kallikrein related peptidase 7 Protein, Klk7 Protein, KLK7 Protein

Hintergrund: Recombinant Human Kallikrein 7 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Glu23-Arg253) of Human KLK7 fused with a polyhistidine tag at the C-terminus.
Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.

Molekulargewicht: 26.17 kDa

UniProt: P49862

Pathways: Komplementsystem