CRHBP Protein (AA 25-322) (His tag)

Produktnummer ABIN1096439

Produktdetails

Target: CRHBP (Corticotropin Releasing Hormone Binding Protein (CRHBP))

Protein-Typ: Recombinant

Proteineigenschaft: AA 25-322

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses CRHBP Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Corticotropin-Releasing Factor-Binding Protein/CRHBP (C-6His)

Sequenz: YLELREAADY DPFLLFSANL KRELAGEQPY RRALRCLDML SLQGQFTFTA DRPQLHCAAF FISEPEEFIT IHYDQVSIDC QGGDFLKVFD GWILKGEKFP SSQDHPLPSA ERYIDFCESG LSRRSIRSSQ NVAMIFFRVH EPGNGFTLTI KTDPNLFPCN VISQTPNGKF TLVVPHQHRN CSFSIIYPVV IKISDLTLGH VNGLQLKKSS AGCEGIGDFV ELLGGTGLDP SKMTPLADLC YPFHGPAQMK VGCDNTVVRM VSSGKHVNRV TFEYRQLEPY ELENPNGNSI GEFCLSGLVD HHHHHH

Produktmerkmale: Recombinant Human Corticotropin-Releasing Factor-Binding Protein/CRHBP is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Tyr25-Leu322) of Human CRHBP fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150mm NaCl, pH 7.5.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 3 months

Antigendetails

Target: CRHBP (Corticotropin Releasing Hormone Binding Protein (CRHBP))

Andere Bezeichnung: crhbp (CRHBP Produkte)

Synonyme: crh-BP Protein, GB14094 Protein, zgc:91905 Protein, CRHBP Protein, CRH-BP Protein, CRF-BP Protein, CRFBP Protein, Crfbp Protein, crhbp-A Protein, gene E Protein, corticotropin releasing hormone binding protein Protein, corticotropin releasing hormone binding protein S homeolog Protein, CRHBP Protein, crhbp Protein, crh-BP Protein, Crhbp Protein, crhbp.S Protein

Sub Type: Fusionprotein

Hintergrund: Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Difference between CRHBP from different species exist, human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. CRHBP is presumed to either sequester CRH, rendering it unavailable to cells or transport it to target tissues. Although CRF-BP concentration in the human peripheral circulation is normally low, it increases throughout pregnancy and fall back rapidly after parturition.
Alternative Names: Corticotropin-Releasing Factor-Binding Protein, CRF-BP, CRF-Binding Protein, Corticotropin-Releasing Hormone-Binding Protein, CRH-BP, CRHBP, CRFBP

Molekulargewicht: 34.38 kDa

UniProt: P24387

Pathways: Negative Regulation of Hormone Secretion