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anti-Mouse (Murine) SPRED1 Antikörper:
anti-Human SPRED1 Antikörper:
anti-Rat (Rattus) SPRED1 Antikörper:
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Human Polyclonal SPRED1 Primary Antibody für ICC, IF - ABIN4355739
Baras, Gandhi, Munari, Faraj, Shultz, Marchionni, Schoenberg, Hahn, Hoque, Hoque, Berman, Bivalacqua, Netto: Identification and Validation of Protein Biomarkers of Response to Neoadjuvant Platinum Chemotherapy in Muscle Invasive Urothelial Carcinoma. in PLoS ONE 2015
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
SPREDs promote self-renewal and inhibit mesodermal differentiation of murine ES cells by selective suppression of the ERK/MAPK (zeige MAPK1 Antikörper) signaling pathway in pluripotent cells
The data suggest that Spred1 negatively regulates group 2 innate lymphoid cell development and functions through the suppression of the Ras-ERK (zeige EPHB2 Antikörper) pathway.
Microrna-126 was transported into recipient human coronary artery endothelial cells by endothelial microparticles and functionally regulated the target protein sprouty-related, EVH1 domain-containing protein 1 (SPRED1).
show that neurofibromin (zeige NF1 Antikörper), the NF1 (zeige NF1 Antikörper) gene product, is a Spred1-interacting protein that is necessary for Spred1's inhibitory function
The results suggest that Spred1 negatively regulates mast cell activation, which is modulated by miR126.
SPRED1 is a likely substrate of SHP2 (zeige PTPN11 Antikörper), whose tyrosine dephosphorylation is required to attenuate the inhibitory action of SPRED1 in the Ras/ERK (zeige EPHB2 Antikörper) pathway.
Data show that both SPRED1 and SPRED2 (zeige SPRED2 Antikörper) inhibit the ability of DYRK1A (zeige DYRK1A Antikörper) to phosphorylate its substrates.
These data suggest that Spreds are key regulators of RhoA (zeige RHOA Antikörper)-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis.
Spred-1 and Spred-2 (zeige SPRED2 Antikörper) were found to be expressed predominantly in brain
The EVH1 domain of Spred1 binds to the noncatalytic portion of the GAP-related domain of neurofibromin (zeige NF1 Antikörper).
Results provide genetic evidence that miR (zeige MLXIP Antikörper)-126, through its target gene Spred-1, plays a critical role in the development of retinal vascular layers.
In one case we identified a nonsense mutation c.46C>T (p.Arg16*) in exon 2 of SPRED1 gene, confirming diagnosis of Legius syndrome. This mutation was reported previously.
PURA (zeige PURA Antikörper) may be a potential target of miR (zeige MLXIP Antikörper)-144 and observed downregulation of PURA (zeige PURA Antikörper) may be caused by increased expression of miR (zeige MLXIP Antikörper)-144. The other predicted target of miR (zeige MLXIP Antikörper)-144 SPRED1, was found to be downregulated in 69 per cent EC tissues as compared to matched distant non-malignant tissues.
Data suggest SPRED1 EVH1 domain interacts with NF1 (zeige NF1 Antikörper) GRD domain [N-term. 16AA/C-term. 20AA of GTPase-activating protein (zeige RASA1 Antikörper)-related domain]; SPRED1 EVH1 and NF1 (zeige NF1 Antikörper) GRD mutations observed in Legius syndrome reduce binding affinity between EVH1/GRD domains.
SPRED1 decreased expression correlated with genetic features of AML (zeige RUNX1 Antikörper). Our study reveals a new mechanism which contributes to deregulate RAS MAPK (zeige MAPK1 Antikörper) pathway in the vast majority of paediatric AMLs
Antisense-mediated knockdown (anti-miR (zeige MLXIP Antikörper)) revealed that miR (zeige MLXIP Antikörper)-206/21 coordinately promote RAS-ERK (zeige EPHB2 Antikörper) signaling and the corresponding cell phenotypes by inhibiting translation of the pathway suppressors RASA1 (zeige RASA1 Antikörper) and SPRED1.
SPRED1 seems to play an important role in recruiting neurofibromin (zeige NF1 Antikörper) to the plasma membrane. (Review)
Older age and deletions of IKZF1 (zeige IKZF1 Antikörper) and SPRED1 were also associated with poor overall survival of pediatric B-cell precursor acute lymphoblastic leukemia.
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
sprouty-related, EVH1 domain-containing protein 1
, sprouty-related protein with EVH-1 domain 1
, sprouty-related, EVH1 domain containing 1
, sprouty-related, EVH1 domain-containing protein 1-like
, sprouty-related protein 1 with EVH-1 domain
, suppressor of Ras/MAPK activation
, sprouty protein with EVH-1 domain 1, related sequence