SPRED1 Antikörper (AA 250-300)

Produktnummer ABIN6990996

Produktdetails anti-SPRED1 Antikörper

Target: SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))

Bindungsspezifität: AA 250-300

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPRED1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: This Spred1 antibody is predicted to have no cross-reactivity to Spred2 or Spred3.

Aufreinigung: Spred1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Spred1 antibody was raised against a 14 amino acid synthetic peptide near the center of the human Spred1. The immunogen is located within amino acids 250 - 300 of Spred1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Spred1 antibody can be used for detection of Spred1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Spred1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Spred1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SPRED1

Target: SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))

Andere Bezeichnung: Spred1 (SPRED1 Produkte)

Synonyme: fb14c08 antikoerper, fj51c03 antikoerper, zgc:85707 antikoerper, wu:fb14c08 antikoerper, wu:fj51c03 antikoerper, Xspred1 antikoerper, Xtspred1 antikoerper, 5730461F13Rik antikoerper, AL024345 antikoerper, AW047647 antikoerper, NFLS antikoerper, hSpred1 antikoerper, spred-1 antikoerper, sprouty-related, EVH1 domain containing 1 antikoerper, sprouty related EVH1 domain containing 1 antikoerper, sprouty related, EVH1 domain containing 1 antikoerper, sprouty related, EVH1 domain containing 1 L homeolog antikoerper, SPRED1 antikoerper, sprouty protein with EVH-1 domain 1, related sequence antikoerper, spred1 antikoerper, SPRED1 antikoerper, spred1.L antikoerper, Bm1_51610 antikoerper, Spred1 antikoerper

Hintergrund: Spred1 Antibody: The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes, it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).

Molekulargewicht: Predicted: 49 kDa

Observed: 498 kDa

Gen-ID: 161742

NCBI Accession: NP_689807

UniProt: Q7Z699

Pathways: Positive Regulation of Response to DNA Damage Stimulus