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anti-Human MCU Antikörper:
anti-Mouse (Murine) MCU Antikörper:
anti-Rat (Rattus) MCU Antikörper:
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Human Polyclonal MCU Primary Antibody für ICC, IF - ABIN4288500
Baughman, Perocchi, Girgis, Plovanich, Belcher-Timme, Sancak, Bao, Strittmatter, Goldberger, Bogorad, Koteliansky, Mootha: Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. in Nature 2011
Show all 8 Pubmed References
MICU2 restricts spatial crosstalk between InsP3R (zeige ITPR1 Antikörper) and MCU channels by regulating threshold and gain of MICU1 (zeige MICU1 Antikörper)-mediated inhibition and activation of MCU.
The results highlight the dynamic nature of uniporter subunit assembly, which must be tightly regulated to ensure proper mitochondrial responses to intracellular Ca(2 (zeige CA2 Antikörper)+) signals.
MCU expression returned to physiological levels in visceral adipose tissue of patients after weight loss by bariatric surgery. Altered mitochondrial calcium flux in fat cells may play a role in obesity and diabetes and may be associated with the differential metabolic profiles of visceral and subcutaneous adipose tissue.
Mitochondrial calcium uniporter plays an important role in hyperglycaemia-induced endothelial cell dysfunction.
The studies findings in aging human skeletal muscle confirm the data obtained in mice and propose mitochondrial calcium uniporter and mitochondria-related proteins as potential pharmacological targets to counteract age-related muscle loss.
decreased MCU expression in hypertensive with mutation cells contributed to dysregulated Ca(2 (zeige CA2 Antikörper)+) uptake into the mitochondria
The molecular structure and regulation of the MCU complex in addition to its pathophysiological role are discussed with particular attention to striated (zeige NSDHL Antikörper) muscle tissues. Review.
High MCU expression is associated with metastasis in hepatocellular carcinoma.
Here, the authors determine the transmembrane orientation of EMRE, and show that its known MCU-activating function is mediated by the interaction of transmembrane helices from both proteins.
It has been shown that the propagation of the TRPV1 (zeige TRPV1 Antikörper)-induced cytosolic calcium and sodium fluxes into mitochondria is dependent on coordinated activity of NCLX (zeige SLC24A6 Antikörper) and MCU.
Results suggest that inhibition of MCU attenuates Abeta (zeige APP Antikörper)-induced mcroglial apoptosis, and that it does so through modulation of reactive oxygen species-mediated endoplasmic reticulum stress. Understanding the apparent links between endoplasmic reticulum stress, oxidative stress and MCU could lead to the development of therapeutic strategies targeting Abeta (zeige APP Antikörper)-mediated microglial death.
These data indicate that Ca(2 (zeige CA2 Antikörper)+) uptake via mitochondrial uniporter contributes to palmitic acid-induced apoptosis in mouse podocytes.
a possible role for tissue-specific stoichiometry between the Ca(2 (zeige CA2 Antikörper)+)-sensing regulators (MICUs) and pore unit (MCU) of the uniporter, was investigated.
MCUR1 binds to MCU and EMRE and function as a scaffold factor.
MCU and EMRE proteins were mainly targeting to the IMM-outer mitochondrial membrane.
Regulation of mitochondrial Ca(2 (zeige CA2 Antikörper)+) suggests that MCU may play a pivotal role in the development of fibrosis and could potentially be a therapeutic target for pulmonary fibrosis.
Reveal a distinct functional role for Cys (zeige DNAJC5 Antikörper)-97 in mitochondrial reactive oxygen species sensing and regulation of MCU activity.
The m-AAA (zeige AAAS Antikörper) protease associated with neurodegeneration limits MCU activity in mitochondria.
Data show that the serine/threonine kinase (zeige CDK4 Antikörper) LKB1 (zeige STK11 Antikörper) regulates mitochondrial calcium uniporter (MCU)-expression, mitochondria-dependent Ca2 (zeige CA2 Antikörper)+ clearance, and thereby, presynaptic release properties.
This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.
calcium uniporter protein, mitochondrial
, coiled-coil domain-containing protein 109A
, coiled-coil domain containing 109A