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Hypothalamic CRH-expressing neurons orchestrate complex behaviors after stress.
Mice lacking corticotropin-releasing hormone, had an improved ability to escape away from potentially dangerous situations.
our results suggest an inhibitory role of miR (zeige MLXIP Proteine)-212 on the HPA (zeige HPSE Proteine) axis, which acts in a counter-regulatory manner.
Study shows that prolactin (zeige PRL Proteine) was sufficient to suppress corticotrophin-releasing hormone (CRH) mRNA expression in the paraventricular nucleus, however it does not appear to be required for the ongoing regulation of the CRH neurones in lactation.
Study blocked endogenous CRH using 2 chemically distinct antagonists of the principal hippocampal CRH receptor, CRHR1 (zeige CRHR1 Proteine). The antagonists caused a modest reduction of spontaneous excitatory transmission onto CA3 (zeige CA3 Proteine) pyramidal cells, mediated. This was accompanied by a decrease in incidence but not amplitude of sharp waves, indicating that CRH synaptic actions are sufficient to alter the output of a complex hippocampal network.
Mice exposed to aggressive confrontations exhibited a similar pattern of species-typical aggressive and non-aggressive behaviors on the first and the last session. Repeated aggressive confrontations promoted an increase in plasma corticosterone. After 10 aggressive confrontation sessions, mice presented a non-significant trend toward reducing hippocampal levels of CRF, which inversely correlated with plasma corticosterone
Data (including data from studies in transgenic mice) suggest that Crh alters Gnrh neuron activity and that estradiol is required for Crh to exert both stimulatory and inhibitory effects on Gnrh neurons. (Crh = corticotropin-releasing hormone; Gnrh = gonadotropin releasing hormone)
The activation of parvalbumin (zeige PVALB Proteine)(+) interneurons during morphine withdrawal was crucial for the induction of the negative emotion and the up-regulation of CRH mRNA levels in the central amygdala.
Psychological stress-derived CRF can breach the established endotoxin tolerance in the intestinal mucosa.
CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the Elevated plus maze.
Significant effects of CNS sensitization on CRF mRNA levels were detected in the Dorsal Striatum (increasing effect).
These results show epigenetic changes in the CRH gene related to severity of suicide attempt in adults and a general psychiatric risk score in adolescents.
Data suggest that corticotrophin-releasing hormone (CRH) is able to stimulate copeptin (zeige AVP Proteine) release in healthy controls suggesting direct interaction of CRH/CRH-receptor signaling and vasopressin (zeige AVP Proteine); these interactions appear to be altered in patients with pituitary disease; copeptin (zeige AVP Proteine) may be serum biomarker of altered CRH/CRH-receptor signaling in pituitary diseases.
The development of disorders related to heightened stress sensitivity and dysregulation of stress-coping mechanisms appears to involve regulatory mechanisms of the CRH family members. The purpose of this review is to summarize the most significant discoveries related to CRH over time. [review]
A significant increase in CRH and CRHR-1 (zeige CRHR1 Proteine) expression was significantly correlated with psychological stress in vitiligo (zeige MITF Proteine).
Corticotrophin-releasing hormone accelerated tumor angiogenesis by upregulating VEGF (zeige VEGFA Proteine) expression and secretion in colon cancer cells.
This study found that the expressions of CRH and CRHR1 (zeige CRHR1 Proteine) were significantly higher in the epileptogenic tissues of patients with IS than in the control group.
The authors propose that conditions impacting on epiallele distribution influence the number of transcriptionally active CRH gene copies in the trophoblast cell population determining the gestational trajectory of placental CRH production in normal and pathological pregnancies.
Neuroimmune-endocrine events may lead to overactivity of sympathetic nervous system that triggers cascade of pathologic conditions in ovary in polycystic ovary syndrome (PCOS). Data suggest that women with PCOS exhibit reduction of CRH and NGF (zeige NGFB Proteine); reduction of CRH and NGF (zeige NGFB Proteine) may be under influence of sympathetic nervous system and may reflect deficit of neuronal stress-adaptation in PCOS patients. (NGF (zeige NGFB Proteine) = nerve growth factor)
brain activation in response to colorectal distention is enhanced after CRH injection in Irritable bowel syndrome patients compared to healthy controls
Evidence is provided for porcine corticotropin releasing hormone (CRH) as a quantitative trait locus (QTL) affecting growth and body composition. (corticotropin releasing hormone; CRH; CRF)
CRH inhibits local progesterone production from luteal cells in swine corpus lutem.
CRF-mediated cytoprotection occurs through the slow and tightly controlled apoptotic pathway.
We show that the CRF system is expressed in fish heart, is upregulated by hypoxia, and is cytoprotective.
Rigorous acute stressor stimuli induce behavioral changes, accompanied by an increase of cortisol levels with delayed control of CRH mRNA expression.
CRF localized in the preoptic area, periventricular hypothalamic and tectal regions, and dorsal part of the trigeminal motor nucleus.
The results of this study indicated that chronic CRF overexpression in primates not only increases Anxious Temperament but also affects metabolism and connectivity within components of Anxious Temperament 's neural circuitry.
We show that -2232C>G alters DNA x protein interactions and confers decreased sensitivity of the CRH promoter to glucocorticoids in vitro.
Data suggest that CRH promoter variation that confers increased stress reactivity increases the risk for alcohol use disorders in stress-exposed individuals.
The association has been reported between polymorphisms of the CRH and POMC (zeige POMC Proteine) genes with economic traits in Korean cattle.
CRH is a promising candidate gene for a concordant QTL related to lipid metabolism in mammals.
corticotropin-releasing factor mRNA fluctuated with food intake in the hypothalamus, pretectum, and optic tectum; CRF mRNA decreased 6 h after a meal and remained low through 31 days of food deprivation
Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
, corticotropin releasing factor
, corticotropin-releasing factor
, corticotropin-releasing hormone
, corticotropin releasing hormone
, corticotrophin-releasing factor
, corticotropin releasing hormone, gene 1
, corticotropin-releasing factor b
, corticotropin releasing hormone b
, Corticotropin-releasing hormone
, corticotropin releasing hormone a
, corticotropin-releasing factor a