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Human MTOR Protein expressed in HEK-293 Cells - ABIN2726555
Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016
Studied combination of metformin and nutlin-3a on malignant mesothelioma. Results indicate possible interactions between metformin/nutlin-3a and mTOR and p53 (zeige TP53 Proteine) signal pathways.
AKAP1 (zeige AKAP1 Proteine) is a transcriptional target of Myc (zeige MYC Proteine), and it supports mTOR pathway and the growth of cancer cells.
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (zeige INS Proteine) activates mTORC2 (zeige CRTC2 Proteine) remains poorly defined.
Our data indicated that miR (zeige MLXIP Proteine)-451 relays environmental signals by upregulating the activity of AMPK (zeige PRKAA1 Proteine) signaling, thereby modulating the activation of mTOR and Rac1/cofilin (zeige CFL1 Proteine) which, in turn, play key roles in glioma cell proliferation and migration, respectively. Our results highlight the need to consider opposing roles of a therapeutic target which, while suppressing tumor cell proliferation, could also promote cell infiltratio
Combining a dual PI3K (zeige PIK3CA Proteine)/mTOR inhibitor with MEK (zeige MAP2K1 Proteine) inhibitors may be a relevant approach to increase anti-tumor activity and prevent drug resistance in patients with leiomyosarcomas.
Suggest that hyperactivation of the mTOR pathway is involved in the development of endometrial hyperplasia with aging.
our findings suggested that MCM7 (zeige MCM7 Proteine) promoted tumor cell proliferation, colony formation and migration of ESCC cells via activating AKT1 (zeige AKT1 Proteine)/mTOR signaling pathway
MED15 (zeige MED15 Proteine) overexpression arises during androgen deprivation therapy via hyper-activation of PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/mTOR signaling pathway in prostate cancer cells.
Telmisartan suppressed human esophageal adenocarcinoma cell proliferation and tumor growth by inducing cell cycle arrest via the AMPK (zeige PRKAA1 Proteine)/mTOR pathway.
mTOR signaling contributes to PGRN (zeige GRN Proteine)-stimulated carcinogenesis of cervical cancer
mTOR mediates metabolic adaptation of antigen-presenting cells in distinct tissues, influencing the immunological character of allergic inflammation.
mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR (zeige VLDLR Proteine) Loss
our results show that the phosphorylation of 4E-BP1 (zeige EIF4EBP1 Proteine) promotes translation at the onset of meiosis to support the spindle assembly and suggest an important role of CDK1 (zeige CDK1 Proteine) and mTOR kinases in this process
Inhibition of mTOR complex 1 is closely associated with aging and prolonged life span of fission yeast.
Abeta (zeige APP Proteine) increases the expression of mTOR and p-mTOR at the site of Ser2448, and the stimulation of Abeta (zeige APP Proteine) is likely to depend on sirtuin 1 (zeige SIRT1 Proteine), PPARgamma (zeige PPARG Proteine), and PGC-1beta pathway in regulating mTOR expression.
In mTOR gene deletion, the astrocyte population exhibited a lower seizure frequency compared with controls in an animal model of temporal lobe epilepsy.
UVB-irradiated or aged mice skin revealed that mTORC2 (zeige CRTC2 Proteine) activity was significantly upregulated which in turn increased Akt (zeige AKT1 Proteine) activation and Akt (zeige AKT1 Proteine)-dependent IkappaB kinase alpha (zeige CHUK Proteine) (IKKalpha (zeige CHUK Proteine)) phosphorylation, and The increased mTORC2 (zeige CRTC2 Proteine) signaling pathway during skin aging were associated to NF-kappaB (zeige NFKB1 Proteine) activation.
Mitogen-activated protein kinase (zeige MAPK1 Proteine) interacting protein (zeige CIB1 Proteine) kinases (Mnks) control translation by phosphorylation of eIF4E (zeige EIF4E Proteine), whereas the mTOR kinase phosphorylates/de-activates the eIF4E (zeige EIF4E Proteine) inhibitor, 4E-BP1 (zeige EIF4EBP1 Proteine), to release translational repression.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (zeige ESCO2 Proteine) cells and supports that normal gene expression and translation requires ESCO2 (zeige ESCO2 Proteine) function.
By inhibiting mTOR signaling via Fbxw7 (zeige FBXW7 Proteine), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (zeige TP53 Proteine).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (zeige PPARG Proteine). In summary, PPARg (zeige PPARG Proteine) plays an important role in the regulation of IGF-1 (zeige IGF1 Proteine) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (zeige PRKAA1 Proteine)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (zeige GUCA2B Proteine) modulates (Na++K+)ATPase (zeige ATP1A1 Proteine) in a proximal tubule cells via cGMP/protein kinase (zeige CDK7 Proteine) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (zeige CCND1 Proteine), and CCNE1 (zeige CCNE1 Proteine).
L-Glutamine enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (zeige RPS6 Proteine)-EIF4EBP1 (zeige EIF4EBP1 Proteine) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (zeige MAP1LC3A Proteine), B and autophagy-associated genes (ATG5 (zeige ATG5 Proteine), mTOR, Beclin-1 (zeige BECN1 Proteine)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (zeige GATM Proteine) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
AnxA2 (zeige ANXA2 Proteine) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (zeige SREBF1 Proteine)/Cyclin D1 (zeige CCND1 Proteine) signaling pathway.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (zeige YWHAG Proteine) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (zeige JAK2 Proteine)-STAT5 (zeige STAT5A Proteine) and mTOR signaling pathways.
Insulin (zeige INS Proteine)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (zeige IGF1 Proteine) down-regulated functional IGF-I receptor (zeige IGF1R Proteine) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (zeige IGF1R Proteine) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (zeige INS Proteine), and prolactin (zeige PRL Proteine) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (zeige RPS6 Proteine) kinase (zeige RPS6KB1 Proteine) signaling in an AKT (zeige AKT1 Proteine)-independent manner
mTOR links IGF-I (zeige IGF1 Proteine) and EGF (zeige EGF Proteine) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin