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Human MTOR Protein expressed in HEK-293 Cells - ABIN2726555
Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016
the present study showed that tetrandrine induced autophagy in human bladder cancer cells by regulating the AMPK (zeige PRKAA1 Proteine)/mTOR signaling pathway, which contributed to the apoptosis induction by tetrandrine, indicating that tetrandrine may be a potential anticancer candidate for the treatment of bladder cancer, and autophagy may be a possible mechanism for cancer therapy.
mTORC1 or mTORC2 (zeige CRTC2 Proteine) silencing markedly decreases the plasma membrane expression of FR-alpha (zeige FOLR1 Proteine) and RFC (zeige RFC1 Proteine) transporter isoforms without affecting global protein expression
In vivo overexpression of iASPP (zeige PPP1R13L Proteine) in SCID (zeige PRKDC Proteine)/NOD mice promoted tumorigenesis and autophagy, with an increase in the conversion from LC3 (zeige MAP1LC3A Proteine)-I to LC3 (zeige MAP1LC3A Proteine)-II. The effects of iASPP (zeige PPP1R13L Proteine) were mediated through activation of mTOR pathway.
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (zeige INS Proteine) activates mTORC2 (zeige CRTC2 Proteine) remains poorly defined.
Results show that mTOR expression level is dowregulated in non-small cell lung cancer (NSCLC) and that its protein phosphylation level is down when NSCLC cells are transfected with miR (zeige MLXIP Proteine)-145.
These results indicate that Merlin (zeige NF2 Proteine)/YAP (zeige YAP1 Proteine)/cMyc (zeige MYC Proteine)/mTOR signaling axis promotes human cholangiocarcinoma (CCA (zeige FBN2 Proteine)) cell proliferation by overriding contact inhibition. We propose that overriding cMycmediated contact inhibition is implicated in the development of CCA (zeige FBN2 Proteine).
This study showed that the mTOR pathway is activated in a high proportion of hereditary pheochromocytomas (PCCs) and paragangliomas (PGLs (zeige PGLS Proteine) with a preferential overactivation of the mTORC1 complex in PGLs (zeige PGLS Proteine) of the head and neck and/or harboring SDHX mutations.
that AKT and mTOR proteins are involved in oral squamous cell carcinoma biology and that GSK3beta itself may drive cervical lymph node metastatic spread of oral squamous cell carcinoma cells
Targeting PPT1 (zeige PPT1 Proteine) blocks mTOR signaling in a manner distinct from catalytic inhibitors, while concurrently inhibiting autophagy, thereby providing a new strategy for cancer therapy.
miRNA-101 level is decreased in RCC (zeige XRCC1 Proteine) tissues/cells, which could be responsible for DNA-PKcs (zeige PRKDC Proteine) overexpression and DNA-PKcs (zeige PRKDC Proteine) mediated oncogenic actions; DNA-PKcs (zeige PRKDC Proteine) over-expression regulates mTORC2 (zeige CRTC2 Proteine)-AKT (zeige AKT1 Proteine) activation, HIF-2alpha (zeige EPAS1 Proteine) expression and RCC (zeige XRCC1 Proteine) cell proliferation
Ggpps (zeige GGPS1 Proteine) deletion enhanced Rheb (zeige RHEB Proteine) farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation
mTOR is crucial for T-cell accumulation in the GI tract and for establishing local adaptive immunity against pathogens.
Data show that mammalian/mechanistic target of rapamycin (mTOR) perturbation alters the suprachiasmatic nucleus (SCN (zeige SRI Proteine)) clock oscillations.
These data demonstrate that the activated mTOR by Erk1/2 results in energy consumption, which in turn leads to endoplasmic reticulum stress signaling and thus induces apoptosis in high glucose-treated podocytes.
Nesfatin-1 (zeige NUCB2 Proteine) promotes the differentiation of brown adipocytes likely through the mTOR dependent mechanism.
Inhibition of mammalian target of rapamycin (mTOR) activation using rapamycin restored Mb mRNA expression to control levels. Lipid supplementation had no effect on Mb gene expression. Thus, IGF-1 (zeige IGF1 Proteine)-induced anabolic signaling can be a strategy to improve muscle size under mild hypoxia, but lowers Mb gene expression
These results demonstrate that mTOR acts as a molecular rheostat of natural killer cell reactivity controlled by educating receptors and uncover how cytokine stimulation overcomes natural killer cell education.
ResultsPIA suppressed phosphorylation of all mTOR proteins
MTOR plays a critical role in the regulation of cortical interneuron number and autophagy in the developing brain.
in the central nervous systems (CNS), the mammalian target of rapamycin (mTOR) pathway plays a critical role in regulating the regenerative capacity of neurons.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (zeige ESCO2 Proteine) cells and supports that normal gene expression and translation requires ESCO2 (zeige ESCO2 Proteine) function.
By inhibiting mTOR signaling via Fbxw7 (zeige FBXW7 Proteine), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (zeige TP53 Proteine).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (zeige PPARG Proteine). In summary, PPARg (zeige PPARG Proteine) plays an important role in the regulation of IGF-1 (zeige IGF1 Proteine) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (zeige PRKAA1 Proteine)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (zeige GUCA2B Proteine) modulates (Na++K+)ATPase (zeige ATP1A1 Proteine) in a proximal tubule cells via cGMP/protein kinase (zeige CDK7 Proteine) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (zeige CCND1 Proteine), and CCNE1 (zeige CCNE1 Proteine).
L-Glutamine enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (zeige RPS6 Proteine)-EIF4EBP1 (zeige EIF4EBP1 Proteine) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (zeige MAP1LC3A Proteine), B and autophagy-associated genes (ATG5 (zeige ATG5 Proteine), mTOR, Beclin-1 (zeige BECN1 Proteine)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (zeige GATM Proteine) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
AnxA2 (zeige ANXA2 Proteine) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (zeige SREBF1 Proteine)/Cyclin D1 (zeige CCND1 Proteine) signaling pathway.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (zeige YWHAG Proteine) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (zeige JAK2 Proteine)-STAT5 (zeige STAT5A Proteine) and mTOR signaling pathways.
Insulin (zeige INS Proteine)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (zeige IGF1 Proteine) down-regulated functional IGF-I receptor (zeige IGF1R Proteine) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (zeige IGF1R Proteine) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (zeige INS Proteine), and prolactin (zeige PRL Proteine) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (zeige RPS6 Proteine) kinase (zeige RPS6KB1 Proteine) signaling in an AKT (zeige AKT1 Proteine)-independent manner
mTOR links IGF-I (zeige IGF1 Proteine) and EGF (zeige EGF Proteine) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin