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Human MTOR Protein expressed in HEK-293 Cells - ABIN2726555
Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016
dual PI3K (zeige PIK3CA Proteine) and mTOR inhibitor, BEZ235 with the HDAC (zeige HDAC3 Proteine) inhibitor Trichostatin A (TSA (zeige PRDX2 Proteine)) significantly increased anti-tumor activities compared with BEZ235 and TSA (zeige PRDX2 Proteine) alone, suggesting a combination treatment for non-small-cell lung cancer (NSCLC).
cellular vacuolization, represents a condition of profound lysosome stress, and cells sense and respond to this stress by facilitating mTOR-dependent TFEB (zeige TFEB Proteine) nucleus translocation in an effort to restore lysosome homeostasis.
Dual PI3K (zeige PIK3CA Proteine)/mTOR inhibition represents an effective therapeutic strategy in uterine leiomyosarcoma, and p-S6(S240) expression is a potential predictive biomarker for response to treatment.
PI3K/mTOR inhibitors with weak affinities for ABC transporters can achieve target inhibition in brain (tumors), but have modest single-agent efficacy and combinations with (BBB penetrable) inhibitors of other activated pathways may be required
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (zeige INS Proteine) activates mTORC2 (zeige CRTC2 Proteine) remains poorly defined.
Studied the prognostic value of HER2 (zeige ERBB2 Proteine)-HER3 (zeige ERBB3 Proteine) and p-mTOR expression in gastric cancer tissue. HER3 (zeige ERBB3 Proteine) overexpression was associated with depth of invasion; HER2 (zeige ERBB2 Proteine)-HER3 (zeige ERBB3 Proteine) overexpression corresponded to gradually shortened 5-year overall survival; p-mTOR overexpression was found to be associated with patient age, tumor location, depth of invasion.
PI3K (zeige PIK3CA Proteine)-PTEN upregulated-mTORC1 and mTORC2 (zeige CRTC2 Proteine) complex plays a critical role in controlling BMAL1 (zeige ARNTL Proteine), establishing a connection between PI3K (zeige PIK3CA Proteine) signaling and the regulation of circadian rhythm, ultimately resulting in deregulated BMAL1 (zeige ARNTL Proteine) in tumor cells with disrupted PI3K (zeige PIK3CA Proteine) signaling
Multiple RRAGC (zeige RRAGC Proteine) mutations demonstrated elevated MTOR activation.
MLN0128 selectively targeted and functionally inhibited acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) stem/progenitor cells with high AKT (zeige AKT1 Proteine)/mTOR kinase signaling activity.
Combined treatment with gamma-irradiation (gammaIR) and a dual PI3K (zeige PIK3CA Proteine)/mTOR inhibitor causes loss of stemness and of FoxO1 (zeige FOXO1 Proteine)/3 proteins in p53 (zeige TP53 Proteine)-proficient glioblastoma multiforme stem cells (GBM-SCs (zeige TWIST1 Proteine)).
In mTOR gene deletion, the astrocyte population exhibited a lower seizure frequency compared with controls in an animal model of temporal lobe epilepsy.
UVB-irradiated or aged mice skin revealed that mTORC2 (zeige CRTC2 Proteine) activity was significantly upregulated which in turn increased Akt (zeige AKT1 Proteine) activation and Akt (zeige AKT1 Proteine)-dependent IkappaB kinase alpha (zeige CHUK Proteine) (IKKalpha (zeige CHUK Proteine)) phosphorylation, and The increased mTORC2 (zeige CRTC2 Proteine) signaling pathway during skin aging were associated to NF-kappaB (zeige NFKB1 Proteine) activation.
Mitogen-activated protein kinase (zeige MAPK1 Proteine) interacting protein (zeige CIB1 Proteine) kinases (Mnks) control translation by phosphorylation of eIF4E (zeige EIF4E Proteine), whereas the mTOR kinase phosphorylates/de-activates the eIF4E (zeige EIF4E Proteine) inhibitor, 4E-BP1 (zeige EIF4EBP1 Proteine), to release translational repression.
Cul-1 (zeige CUL1 Proteine) deneddylation led to Deptor (zeige DEPTOR Proteine) accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
Trehalose may rescue against insulin (zeige INS Proteine) resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK (zeige MAPK14 Proteine) and Foxo1 (zeige FOXO1 Proteine) without affecting phosphorylation of Akt (zeige AKT1 Proteine).
These findings highlight the importance of autophagy as therapeutic target and suggest that elucidating connections between protein unfolding and mTOR-dependent or mTOR-independent hypertrophic responses is likely to reveal specific therapeutic windows for the treatment of muscle wasting disorders
Data show that activated protein C (zeige PROC Proteine) (aPC (zeige APC Proteine)) inhibited Nlrp3 (zeige NLRP3 Proteine) inflammasome activation via mammalian target of rapamycin complex 1 (mTORC1) signaling.
Collectively, our findings indicate that miR (zeige MLXIP Proteine)-140 exerts anti-OS efficacy by targeting immune checkpoint molecule PD-L1 (zeige CD274 Proteine) and can be developed as a novel immunotherapeutic agent for the treatment of OS.
Thus, the various regulatory elements that impinge upstream of mTORC1 activation pathways are differentially required for HSC (zeige FUT1 Proteine) homeostasis in vivo.
Loganin is capable of increas-ing the SMN (zeige STMN1 Proteine) protein level under SMN (zeige STMN1 Proteine)-deficient conditions both inin vitro and in vivo models of spinal muscular atrophy via Akt (zeige AKT1 Proteine)/mTOR pathway.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (zeige ESCO2 Proteine) cells and supports that normal gene expression and translation requires ESCO2 (zeige ESCO2 Proteine) function.
By inhibiting mTOR signaling via Fbxw7 (zeige FBXW7 Proteine), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (zeige TP53 Proteine).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (zeige PPARG Proteine). In summary, PPARg (zeige PPARG Proteine) plays an important role in the regulation of IGF-1 (zeige IGF1 Proteine) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (zeige PRKAA1 Proteine)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (zeige GUCA2B Proteine) modulates (Na++K+)ATPase (zeige ATP1A1 Proteine) in a proximal tubule cells via cGMP/protein kinase (zeige CDK7 Proteine) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (zeige CCND1 Proteine), and CCNE1 (zeige CCNE1 Proteine).
L-Glutamine enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (zeige RPS6 Proteine)-EIF4EBP1 (zeige EIF4EBP1 Proteine) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (zeige MAP1LC3A Proteine), B and autophagy-associated genes (ATG5 (zeige ATG5 Proteine), mTOR, Beclin-1 (zeige BECN1 Proteine)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (zeige GATM Proteine) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
AnxA2 (zeige ANXA2 Proteine) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (zeige SREBF1 Proteine)/Cyclin D1 (zeige CCND1 Proteine) signaling pathway.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (zeige YWHAG Proteine) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (zeige JAK2 Proteine)-STAT5 (zeige STAT5A Proteine) and mTOR signaling pathways.
Insulin (zeige INS Proteine)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (zeige IGF1 Proteine) down-regulated functional IGF-I receptor (zeige IGF1R Proteine) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (zeige IGF1R Proteine) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (zeige INS Proteine), and prolactin (zeige PRL Proteine) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (zeige RPS6 Proteine) kinase (zeige RPS6KB1 Proteine) signaling in an AKT (zeige AKT1 Proteine)-independent manner
mTOR links IGF-I (zeige IGF1 Proteine) and EGF (zeige EGF Proteine) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin