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The borders of this novel topologically associating domains (TADs)correspond to the original 5'- and 3'- borders of the PAX3 (zeige PAX3 Proteine) and FOXO1 TADs, respectively, suggesting that TAD (zeige CRTAM Proteine) organisation precedes the formation of regulatory long-range interactions. Our results demonstrate that, upon translocation, novel regulatory landscapes are formed allowing new intra-TAD (zeige CRTAM Proteine) interactions between the original loci involved
In this study, the long noncoding RNA MALAT1, confirmed to be significantly upregulated in OS, is first shown to be capable of promoting proliferation and migration by directly suppressing miR (zeige MLXIP Proteine)-26a-5p in OS cells. Authors have identified forkhead box O1 (FOXO1) as a transcriptional factor of MALAT1 that can negatively regulate MALAT1.
miR (zeige MLXIP Proteine)-145 suppressed STAT3 (zeige STAT3 Proteine) phosphorylation at Tyr705 and increased foxo1 promoter transcriptional activity in T24 cells, but not in T24T cells, suggesting a role of STAT3 (zeige STAT3 Proteine) in the divergent responses to miR (zeige MLXIP Proteine)-145.
KLF4 (zeige KLF4 Proteine) transcriptionally repressed FOXO1 expression in glioma cells, contributing to glioma cell invasion and growth.
this study provides the first evidence that FOXO1 can reverse epithelial-to-mesenchymal transition in hepatocellular carcinoma via the transcription inducers Snail (zeige SNAI1 Proteine), Slug, ZEB1, ZEB2 and Twist1 (zeige TWIST1 Proteine), with ZEB2 playing a particularly critical role in this process. Furthermore, FOXO1 disrupts TGF-beta (zeige TGFB1 Proteine)-induced epithelial-to-mesenchymal transition.
The data reveal a novel mechanism in which the elevated miR (zeige MLXIP Proteine)-425 in IBD mediates pathogenic Th17 cell generation through down-regulation of Foxo1.
miR (zeige MLXIP Proteine)-181a2/181b2 prominently dampened cell-cycle progression, suppressed cell growth, and promoted apoptosis of tumor cells in vitro They also effectively impeded tumor formation and growth in vivo miR (zeige MLXIP Proteine)-181a2/181b2 exert the tumor suppressor ability by depressing the direct target PIK3R3 (p55gamma) and consequently modulating the PIK3R3/Akt (zeige AKT1 Proteine)/FoxO (zeige FOXO3 Proteine) signaling pathway
A high extent more than 25% of BRAF (zeige BRAF Proteine)(V600E) alleles may be associated with disease outcome in PTC (zeige F9 Proteine) patients.
Low FOXO1 expression is associated with hepatocellular carcinoma.
Combined treatment with gamma-irradiation (gammaIR) and a dual PI3K (zeige PIK3CA Proteine)/mTOR (zeige FRAP1 Proteine) inhibitor causes loss of stemness and of FoxO1/3 proteins in p53 (zeige TP53 Proteine)-proficient glioblastoma multiforme stem cells (GBM-SCs (zeige TWIST1 Proteine)).
These results indicate that miR (zeige MYLIP Proteine)-182 functions as a FoxO1 inhibitor to antagonize osteoblast proliferation and differentiation, with a subsequent negative effect on osteogenesis.
gas6 (zeige GAS6 Proteine) protects endothelial cells from apoptosis by a mechanism that involves PI3K-Akt (zeige AKT1 Proteine)-dependent inactivation of FOXO1a.
Sirt3 (zeige SIRT3 Proteine) activation is essential to improve autophagy flux by reducing the acetylation modification on FoxO1, which in turn alleviates myocardial hypertrophy.
we found that in db/db (zeige LEPR Proteine) VSMC, the occupancy in promoter regions of inflammatory genes by FOXO1 was reduced.miR-135a increased the inflammatory responses of VSMC involved in complications of vascular diseases by downregulating the expression of FOXO1.
Trehalose may rescue against insulin (zeige INS Proteine) resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 MAPK (zeige MAPK14 Proteine) and Foxo1 without affecting phosphorylation of Akt (zeige AKT1 Proteine).
FoxO1 is a key mediator involved in glucose homeostasis and indicate that 1,25(OH)2D3 improves glucose metabolism and bone development
Data show that the mitochondrial enriched GCN5 (zeige KAT2A Proteine)-like 1 protein (GCN5L1 (zeige BLOC1S1 Proteine)) controls hepatic glucose production by regulating FoxO1 protein levels.
Setdb1 (zeige SETDB1 Proteine) regulates PTEN/AKT (zeige AKT1 Proteine)/FOXO1 pathway to inhibit Spermatogonial stem cells apoptosis.
These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt (zeige AKT1 Proteine)-FoxO1 but not p38 MAPK (zeige MAPK14 Proteine) or Erk1/2 MAPK (zeige MAPK1 Proteine) pathways.
a critical role for FOXO (zeige FOXO3 Proteine) transcription factors in mediating these proliferative versus apoptotic fates
L. donovani triggered AKT (zeige AKT1 Proteine) activation to regulate GSK-3beta/beta-catenin (zeige CTNNB1 Proteine)/FOXO-1 axis.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
let-7g induces porcine granulosa cells apoptosis by inhibiting the MAP3K1 (zeige MAP3K1 Proteine) gene, which promotes FoxO1 expression and dephosphorylation with nuclear accumulation.
inhibition of FoxO1 expression level caused by miR (zeige MYLIP Proteine)-15a/b over-expression had a positive effect on adipogenesis. Thus, we conclude that miR (zeige MYLIP Proteine)-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1
Results show that FoxO1 likely regulates MyHC I (zeige MYH7 Proteine) negatively and MyHC IIx and MyHC IIb (zeige MYH4 Proteine) positively and may play a pivotal role in the determination of muscle fiber type.
Data suggest forkhead box protein O1 (FoxO1) involvement in the regulation of TNF-related apoptosis-inducing ligand TRAIL (zeige TNFSF10 Proteine) and Fas ligand FasL (zeige FASL Proteine) expression during follicular atresia.
Data show that IL-4 (zeige IL4 Proteine) induces upregulation of the junction protein claudin-5 (zeige CLDN5 Proteine) in endothelial cells (ECs) through activation of Jak (zeige JAK3 Proteine)/STAT6 (zeige STAT6 Proteine) and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm.
FoxO1 and C/EBPb (zeige CEBPB Proteine) regulate preadipocyte adipogenesis possibly through C/EBPb (zeige CEBPB Proteine)-> FoxO1-> C/EBPb (zeige CEBPB Proteine) feedback regulatory loop and FoxO1-C/EBPb (zeige CEBPB Proteine) protein complex.
FoxO1 delays and negatively regulates the porcine myoblast differentiation. It may also play a critical role in muscle fiber-type specification through the inhibition of myogenic regulation factors.
concluded that PI 3 (zeige PI3 Proteine)-kinase and Akt (zeige AKT1 Proteine) are activated after renal ischemia/reperfusion and that Akt (zeige AKT1 Proteine) phosphorylation leads to phosphorylation of FKHR and FKHRL1 (zeige FOXO3 Proteine), which may affect epithelial cell fate in acute renal failure.
FoxO1a can regulate p27kip nuclear localization
MicroRNA-183-96-182 cluster regulates bovine granulosa cell function by targeting FOXO1 gene.
downregulation of SIRT1 (zeige SIRT1 Proteine) and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age
FOXO (zeige FOXO3 Proteine) is a key regulator of ROS (zeige ROS1 Proteine)-induced apoptosis in mammalian cells.
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule (zeige NCAM1 Proteine)-1 mRNA.
The results demonstrate pathways through which two different mediators, TNF-alpha (zeige TNF Proteine) and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1.
FoxO1 translocation to the nucleus, and the increase in FoxO1 DNA binding activity in X. laevis liver strongly correlate with the up-regulation of manganese-dependent superoxide dismutase (zeige SOD1 Proteine) and catalase (zeige CAT Proteine) mRNA and protein levels in this organ.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined\; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
forkhead box protein O1
, forkhead box protein O1A
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
, forkhead box O1A
, forkhead box protein O1-A
, fox family transcription factor FoxO1a.1
, foxhead box protein O1-A
, Forkhead box protein O1A
, Forkhead in rhabdomyosarcoma
, forkhead box O1A (rhabdomyosarcoma)
, forkhead box O1a
, forkhead in rhabdomyosarcoma
, forkhead protein 1
, forkhead/winged helix transcription factor FOXO1a
, forkhead box O1
, forkhead box protein O1-like