Henriques, Pattenden, Aguilar, Castanho: "PrP(106-126) does not interact with membranes under physiological conditions." in: Biophysical journal, Vol. 95, Issue 4, pp. 1877-89, (2008) (PubMed).
This peptide increases membrane microviscosity, intracellular Ca2+. Concentration and cell migration in circulating leucocytes, and oxygen production in monocytes and neutrophils. It also induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell lines. PrP (106-126) activates leucocyte migration in a dose-dependent manner. Synonym: PrP (106-126)