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PRNP Produkte

(Prion Protein (PRNP))
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].

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Ausgewählte PRNP Kategorien

PRNP Antikörper

High quality antibodies with extensive validation data.

PRNP ELISA Kits

Reliable ELISA kits for a wide range of species.

PRNP Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene PRNP Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Applikation WB, IHC, IP, ICC
Validierungen
  • (4)
Kat. Nr. ABIN7433921
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, ELISA, FACS
Validierungen
  • (4)
Kat. Nr. ABIN7193415
Menge 0.1 mg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IHC
Validierungen
  • (3)
Kat. Nr. ABIN7260569
Menge 200 μL
Datenblatt Datenblatt

Empfohlene PRNP ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6969500
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6969499
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6958725
Menge 96 tests
Datenblatt Datenblatt

Empfohlene PRNP Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (2)
Kat. Nr. ABIN7275480
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source HEK-293 Cells
Validierungen
  • (1)
Kat. Nr. ABIN7275481
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1316351
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren PRNP Produkten

Goetzl, Elahi, Mustapic, Kapogiannis, Pryhoda, Gilmore, Gorgens, Davidson, Granholm, Ledreux: "Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 4, pp. 5082-5088, (2020) (PubMed).

Hu, Li, You, Zhang, Jin, Huang: "Effects of cellular prion protein on rapid eye movement sleep deprivation-induced spatial memory impairment." in: Journal of integrative neuroscience, Vol. 18, Issue 4, pp. 439-444, (2020) (PubMed).

Cook, Bingham, Besier, Bayley, Hawes, Shearer, Yamada, Bergfeld, Williams, Middleton: "Atypical scrapie in Australia." in: Australian veterinary journal, Vol. 94, Issue 12, pp. 452-455, (2016) (PubMed).

Reil, Bux: "Geno- and phenotyping of human neutrophil antigens." in: Methods in molecular biology (Clifton, N.J.), Vol. 1310, pp. 193-203, (2016) (PubMed).

Ortiz-Pelaez, Georgiadou, Simmons, Windl, Dawson, Arnold, Neocleous, Papasavva-Stylianou: "Allelic variants at codon 146 in the PRNP gene show significant differences in the risk for natural scrapie in Cypriot goats." in: Epidemiology and infection, Vol. 143, Issue 6, pp. 1304-10, (2015) (PubMed).

Wang, Tian, Fan, Chen, Lv, Sun, Zhao, Zhang, Wang, Shi, Gao, Chen, Shao, Dong: "Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrP(Sc) in prion infected cell line via protein interaction." in: The international journal of biochemistry & cell biology, Vol. 62, pp. 24-35, (2015) (PubMed).

Risse, Nicoll, Taylor, Wright, Badoni, Yang, Farrow, Collinge: "Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay." in: The Journal of biological chemistry, Vol. 290, Issue 27, pp. 17020-8, (2015) (PubMed).

Richardson, Tol, Valle-Encinas, Pleguezuelos, Bierings, Geerts, Fernandez-Borja: "The prion protein inhibits monocytic cell migration by stimulating β1 integrin adhesion and uropod formation." in: Journal of cell science, Vol. 128, Issue 16, pp. 3018-29, (2015) (PubMed).

Dvorakova, Vranac, Janouskova, ?ernilec, Koren, Lukan, Nováková, Matej, Holada, ?urin Šerbec: "Detection of the GPI-anchorless prion protein fragment PrP226* in human brain." in: BMC neurology, Vol. 13, pp. 126, (2013) (PubMed).

Mercer, Ma, Watts, Strome, Wohlgemuth, Yang, Cashman, Coulthart, Schmitt-Ulms, Jhamandas, Westaway: "The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6." in: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37241-55, (2013) (PubMed).

Synonyme und alternative Namen zu PRNP

prion protein (PRNP), prion protein (Prnp), prion protein S homeolog (prnp.S), prion protein b (prnpb), AA960666, AI325101, AltPrP, ASCR, CD230, CJD, cjd, GSS, KURU, MGC84114, p27-30, prion, PRIP, Prn, Prn-i, Prn-p, PRNP, prnprs1, PrP, prp, PRP, Prp, prp(c), PrP-1, PrP1, PrP27-30, prP27-30, PrP33-35C, prP33-35C, PrP, PrPc, PRPC, PrPC, PrPSc, Sinc, SIP, stPrP-1, zgc:123004

Bezeichner auf Proteinebene für PRNP

  • CD230 antigen
  • major prion protein
  • prion-related protein
  • prion protein, PrP
  • prion protein, structural
  • major scrapie-associated fibril protein 1
  • prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
  • prion protein PrP
  • prion protein precursor PrP
  • prion protein variant a
  • prion protein variant b
  • 65-21 protein
  • ARIA
  • PR-LP
  • acetylcholine receptor-inducing activity
  • major prion protein homolog
  • prion-like protein
  • prion-like-protein
  • prion protein
  • infectious amyloid
  • Major prion protein
  • major prion protein preproprotein
  • prP
  • prP27-30
  • prP33-35C
  • PrP 27-30
  • prion protein 1
  • prion protein b
  • prion protein, related sequence 1
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