SMAD, Mothers Against DPP Homolog 1 (SMAD1) Peptid
SMAD1
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle SMAD1 Produkte
- SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-SMAD1 antibody (Catalog #: ARP32003_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
- Synonyme
- MLP Peptide, Xmad1 Peptide, Xsmad1 Peptide, bsp1 Peptide, jv4-1 Peptide, jv41 Peptide, madh1 Peptide, madr1 Peptide, smad-1 Peptide, MADH1 Peptide, fb39h09 Peptide, wu:fb39h09 Peptide, wu:fb97e04 Peptide, 2/23 Peptide, CG12399 Peptide, Dmel\\CG12399 Peptide, E(zen)2 Peptide, En(vvl) Peptide, MAD Peptide, Mat Peptide, P-Mad Peptide, P-mad Peptide, PMad Peptide, Smad Peptide, Smad1 Peptide, apg Peptide, c28 Peptide, dMAD Peptide, dMad Peptide, l(2)K00237 Peptide, l(2)k00237 Peptide, mad Peptide, p-Mad Peptide, pMAD Peptide, pMad Peptide, pSmad Peptide, BSP-1 Peptide, BSP1 Peptide, JV4-1 Peptide, JV41 Peptide, MADR1 Peptide, AI528653 Peptide, Madh1 Peptide, Madr1 Peptide, Mlp1 Peptide, MusMLP Peptide, smad1 Peptide, xmad Peptide, SMAD family member 1 Peptide, Mothers against dpp Peptide, SMAD family member 1 L homeolog Peptide, smad1 Peptide, SMAD1 Peptide, Mad Peptide, Smad1 Peptide, smad1.L Peptide
- Hintergrund
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SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Alias Symbols: BSP1, JV4-1, JV41, MADH1, MADR1, BSP-1
Protein Interaction Partner: STUB1,E1A,LEMD3,RAN,SKIL,SMAD4,SMURF2,ACVR1,AKR1B1,ANKRD27,AP2A2,AR,ARHGEF6,ARL4D,BMPR1A,BTBD2,BTG2,COL4A1,ECSIT,EIF2AK4,ELP3,EP300,ERBB2IP,EWSR1,FBXL12,FBXO30,FHL5,FOXG1,GDF6,GLI3,GMEB1,GSC,HBP1,HIPK2,HOXA13,HOXC8,HOXD13,ICK,ING2,INPP4A,KAT2B,LEF1,LEMD3,MAPK1,MBD1,MED6,MEN1,MLL2,NAT9,NEDD9,NEUROG1,NOTCH2,PAK1,PIAS1,PIAS4,PIGQ,PLEKHB1,PREB,PSMB4,PSMD1,PSMD11,PUM1,RAB2B,RAB30,RAB34,RAB38,RAB3B,RAB6B,RAC2,RAN,RAP2A,RASD2,RASL12,RFX1,RHEBL1,RHOG,RPS27A,SF3B1,SKIL,SMAD1,SMAD3,SMAD4,SMAD5,SMAD6,SMARCE1,SMURF1,SMURF2,SNIP1,SNRNP70,SOX5,SQSTM1,STARD13,STUB1,SUV39H1,TGFBR1,TNNT1,TOB1,TRIP6,TTF1,TTF2,UBA52,UBE2Z,UBXN1,UNKL,USP45,VEPH1,VPS24,XPC,XPO1,ZBTB44,ZDHHC3,ZEB2,ZNF423,ZNF510,ZNF521,ZNF76,ZNF8,ZSCAN4,ACVR1,BMP7,CREBBP,DVL1,EP300,ERBB2IP,FOXG1,HIPK2,HOXC8,NEDD9,NEUROG1,OAZ3,PARD3B,PSMB4,RPS27A,RUNX1,RUNX2,RUNX3,SKI,SMAD4,SMAD6,SMURF2,SNIP1,STAT3,Sip1,TGIF1,TOB1,UBA52,ZEB1,ZNF423
Protein Size: 465 - Molekulargewicht
- 52 kDa
- Gen-ID
- 4086
- NCBI Accession
- NM_005900, NP_005891
- UniProt
- Q15797
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