Peroxisome Proliferator-Activated Receptor delta (PPARD) (N-Term) Peptid
PPARD
Reaktivität: Human
Wirt: Synthetic
BP, WB, IHC
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- Target Alle PPARD Produkte
- PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))
- Protein Region
- N-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-PPARD antibody (Catalog #: ARP38764_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))
- Synonyme
- FAAR Peptide, NR1C2 Peptide, NUC1 Peptide, NUCI Peptide, NUCII Peptide, PPARB Peptide, NUC-1 Peptide, Nr1c2 Peptide, PPAR-beta Peptide, PPAR-delta Peptide, PPAR[b] Peptide, PPARdelta Peptide, Pparb Peptide, Pparb/d Peptide, PPARBETA Peptide, ppard Peptide, pparb Peptide, PPARD Peptide, PPAR-D/B Peptide, peroxisome proliferator activated receptor delta Peptide, peroxisome proliferator activator receptor delta Peptide, peroxisome proliferator activated receptor delta S homeolog Peptide, peroxisome proliferator-activated receptor delta Peptide, PPARD Peptide, Ppard Peptide, ppard.S Peptide, ppard Peptide
- Hintergrund
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PPARD is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
Alias Symbols: FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, PPAR-beta, PPARB
Protein Interaction Partner: BCL6,HDAC7,NCOR2,BCL6,DUT,EP300,GADD45B,GADD45G,HDAC1,HDAC2,HDAC3,HDAC7,NCOR1,NCOR2,NR0B2,NRIP1,PEBP1,PPARD,PRDX6,PROX1,RANBP9,RXRA,RXRB,RXRG,SMAD9,SPEN,SRC,CEP350,GADD45G,Gadd45b,HDAC1,HDAC2,HDAC3,HDAC4,NCOR1,NCOR2,PPARD,SPEN
Protein Size: 441 - Molekulargewicht
- 49 kDa
- Gen-ID
- 5467
- NCBI Accession
- NM_001039694, NP_001034783
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