Glucocorticoid Receptor (NR3C1)
(Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))
Protein Region
N-Term
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-NR3C1 antibody (Catalog #: ARP45593_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
NR3C1
Reaktivität: Human, Maus, Rind (Kuh)
Wirt: Synthetic
BP
Applikationshinweise
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
Glucocorticoid Receptor (NR3C1)
(Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1))
Synonyme
GR Peptide, gcr Peptide, grl Peptide, xGR Peptide, gccr Peptide, gr Peptide, zgc:113038 Peptide, NR3C1 Peptide, GCL Peptide, LOC100302444 Peptide, Gcr Peptide, Grl Peptide, Grl-1 Peptide, Grl1 Peptide, GRL Peptide, GCCR Peptide, GCR Peptide, NO Peptide, GR-A Peptide, nr3c1 Peptide, nuclear receptor subfamily 3 group C member 1 Peptide, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Peptide, nuclear receptor subfamily 3, group C, member 1 Peptide, glucocorticoid receptor Peptide, NR3C1 Peptide, nr3c1 Peptide, LOC100302444 Peptide, Nr3c1 Peptide
Hintergrund
NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
Alias Symbols: GCCR, GCR, GR, GRL
Protein Interaction Partner: KDM5A,NCOA2,TP53,ADA,AR,BAG1,CALM1,CALR,CEBPA,CEBPB,CHD9,COPS6,CREB1,CREBBP,DAP3,DCAF6,DDX54,ECD,ETS1,ETS2,FKBP4,FYN,GRIP1,HNRNPU,HSP90AA1,HSPA1A,IDE,IFNGR2,JUN,KDM5A,KPNA2,LCK,MAPK1,MAPK15,MAPK8,MDM2,MED14,NCL,NCOA1,NCOA2,NCOA6,NCOR1,NCOR2,NFKB1,NFKB2,NR2F2,NR2F6,NR3C1,NR3C2,NRIP1,ONECUT1,PBX1,POU1F1,POU2F1,POU2F2,PPARGC1A,PRKACA,PRKDC,PSMC3IP,PTGES3,PTMS,RAF1,RELA,RNF14,SFN,SLC25A4,SMAD3,SMARCA2,SMARCA4,SMARCB1,SMARCC1,SMARCD1,SMARCE1,STAT3,STAT5A,STAT5B,SUMO1,SUMO4,SYT1,TBP,TGFB1I1,TP53,TRIM24,TRIM28,TSG101,TXN,UBB,UBE2I,YWHAH,ZBTB16,ADA,ARPC5,BAG1,CALR,CEBPA,CEBPB,CREB1,CREBBP,DAP3,DAXX,DDX54,ECD,ETS2,FKBP4,HMGB1,HMGB2,HNRNPU,HOXB1,HSP90AA1,HSPA1A,HSPD1,JUN,KDM5A,MED1,MED14,NCL,NCOA1,NCOA2,NCOA3,NCOA4,NCOA6,NCOR1,NCOR2,NEDD4L,NFKB1,NFKB2,NR2F6,NR3C1,NR3C2,NRIP1,ONECUT1,PBX1,PIAS2,POU1F1,POU2F1,POU2F2,PPARGC1A,PSMC3IP,PTGES3,Psmc3ip,RAD9A,RAF1,RAN,RANBP9,RELA,SFN,SFPQ,SMAD3,SMARCA4,SMARCC1,SMARCD1,SMARCE1,STAT3,STAT5B,SVIL,TADA2A,TBP,TDG,TGFB1I1,TP53,TRIM24,TRIM28,TSG101,TXN,YWHAH,ZBTB16